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標題: Plasma matrix metalloproteinase-9 level is better than serum matrix metalloproteinase-9 level to predict gastric cancer evolution
作者: Wu, C.Y.
Wu, M.S.
Chiang, E.P.
Chen, Y.J.
Chen, C.J.
Chi, N.H.
Shih, Y.T.
Chen, G.H.
Lin, J.T.
關鍵字: endothelial growth-factor;cell lung-cancer;matrix metalloproteinases;mmp-2;tissue inhibitors;iv collagenase;gelatinase-b;collection;methods;prognostic marker;breast-cancer;carcinoma
Project: Clinical Cancer Research
期刊/報告no:: Clinical Cancer Research, Volume 13, Issue 7, Page(s) 2054-2060.
Purpose: Matrix metalloproteinase-9 (MMP-9) in blood is a promising new tumor marker. The aims of the present study are to compare the usefulness of plasma and serum MMP-9 levels for predicting gastric cancer development, invasion, and survival. Experimental Design: In this nested case-control study, 114 gastric cancer patients and 87 healthy controls were enrolled. MMP-9 levels and activities were quantitatively measured by ELISA assay and zymography. The results were compared with the occurrence, clinicopathologic features, and outcomes of gastric cancer patients. The follow-up time for all patients was at least 5 years. Results: Serum MMP-9 levels were significantly higher than plasma MMP-9 levels. Both plasma and serum MMP-9 levels correlated significantly with active MMP-9 identified by zymography (P = 0.002 and P = 0.048, respectively). Plasma MMP-9 level was significantly elevated in gastric cancer patients when compared with control subjects (P < 0.001). Serum MMP-9 levels did not differ between the groups. Receiver-operator characteristics analysis showed the values of sensitivity (82.5%) and specificity (65.5%) at the maximum accuracy for plasma MMP-9 at >= 60 ng/mL (P < 0.001). Elevated plasma MMP-9 correlated significantly with lymph node metastasis [odds ratio (OR), 3.43; P = 0.019], lymphatic invasion (OR, 7.58; P = 0.009), and venous invasion (OR, 4.14; P = 0.033). Patients with elevated plasma MMP-9 levels had poorer survival rates than those with normal plasma MMP-9 levels (P = 0.038). Serum MMP-9 level did not correlate well with gastric cancer - invasive phenotypes or survival. Conclusion: Our results suggest plasma MMP-9 level is a better marker than serum MMP-9 level for predicting gastric cancer development and progression.
ISSN: 1078-0432
DOI: 10.1158/1078-0432.ccr-06-2299
Appears in Collections:食品暨應用生物科技學系

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