Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/62042
DC FieldValueLanguage
dc.contributor.authorTang, F.Y.en_US
dc.contributor.author蔣恩沛zh_TW
dc.contributor.authorChiang, E.P.I.en_US
dc.contributor.authorShih, C.J.en_US
dc.date2007zh_TW
dc.date.accessioned2014-06-09T06:26:19Z-
dc.date.available2014-06-09T06:26:19Z-
dc.identifier.issn0955-2863zh_TW
dc.identifier.urihttp://hdl.handle.net/11455/62042-
dc.description.abstractAngiogenesis, the formation of new blood vessels from preexisting capillaries, is essential for tumor progression and metastasis. During tumor neovascularization, vascular endothelial growth factor and ephrin (Eph) families emerge as critical mediators of angiogenesis. The green tea catechin epigallocatechin gallate (EGCG), a tyrosine kinase inhibitor, has been demonstrated in previous studies to be an effective anti angiogenesis agent. However, the inhibitory effect of green tea catechins on ephrin-A1-mediated tumor angiogenesis has not been demonstrated yet. Thus, in this study, we investigated the molecular mechanism of ephrin-A1-mediated cell migration and angiogenesis, as well as the inhibitory effects of EGCG. Here we show that ephrin-A1 mediates endothelial cell migration and regulates vascular remodeling in tumor neovascularization in vitro. We also demonstrated that ephrin-A1-mediated cell migration required the activation of extracellular-regulated kinase (ERK-1/2) but not of phosphatidylinositol-3-kinase. The green tea catechin EGCG inhibited ephrin-A1-mediated endothelial cell migration, as well as tumor angiogenesis, in a dose-dependent manner. Furthermore, EGCG inhibited the ephrin-A1-mediated phosphorylation of EphA2 and EPK-1/2. Taken together, these data indicated that activation of ERK-1/2 plays an essential role in ephrin-A1-mediated cell migration. EGCG inhibited ephrin-A1-mediated endothelial migration and angiogenesis. It suggests a novel antiangiogenesis application of EGCG in cancer chemoprevention. (C) 2007 Elsevier Inc. All rights reserved.en_US
dc.language.isoen_USzh_TW
dc.relationJournal of Nutritional Biochemistryen_US
dc.relation.ispartofseriesJournal of Nutritional Biochemistry, Volume 18, Issue 6, Page(s) 391-399.en_US
dc.relation.urihttp://dx.doi.org/10.1016/j.jnutbio.2006.07.004en_US
dc.subjectepigallocatechin gallateen_US
dc.subjectephrin-A1en_US
dc.subjectEphA2en_US
dc.subjectPI-3Ken_US
dc.subjectERK-1/2en_US
dc.subjectcellen_US
dc.subjectmigrationen_US
dc.subjectangiogenesisen_US
dc.subjectreceptor tyrosine kinaseen_US
dc.subjecteph receptorsen_US
dc.subjectcardiovascular developmenten_US
dc.subjectvascular developmenten_US
dc.subjectgrowth-factorsen_US
dc.subjectcanceren_US
dc.subjectligandsen_US
dc.subjectphosphorylationen_US
dc.subjectsuppressionen_US
dc.subjectephrin-b2en_US
dc.titleGreen tea catechin inhibits ephrin-A1-mediated cell migration and angiogenesis of human umbilical vein endothelial cellsen_US
dc.typeJournal Articlezh_TW
dc.identifier.doi10.1016/j.jnutbio.2006.07.004zh_TW
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeJournal Article-
item.cerifentitytypePublications-
item.fulltextno fulltext-
item.languageiso639-1en_US-
item.grantfulltextnone-
Appears in Collections:食品暨應用生物科技學系
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