Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/62086
DC FieldValueLanguage
dc.contributor.authorHsu, C.L.en_US
dc.contributor.author顏國欽zh_TW
dc.contributor.authorLin, Y.J.en_US
dc.contributor.authorHo, C.T.en_US
dc.contributor.authorYen, G.C.en_US
dc.date2012zh_TW
dc.date.accessioned2014-06-09T06:26:23Z-
dc.date.available2014-06-09T06:26:23Z-
dc.identifier.issn2042-6496zh_TW
dc.identifier.urihttp://hdl.handle.net/11455/62086-
dc.description.abstractThe aim of this work was to study the effects of garcinol and pterostilbene on cell proliferation and adipogenesis in 3T3-L1 cells. The results showed that garcinol and pterostilbene decreased the cell population growth and caused cell cycle arrest at the G2/M phase in 3T3-L1 preadipocytes. During adipocyte differentiation, both garcinol and pterostilbene had inhibitory effects on fat droplet formation and triacylglycerol accumulation. The data indicated that garcinol and pterostilbene could inhibit the glycerol-3-phosphate dehydrogenase (GPDH) activity by 97.8 and 61.5%, respectively, as compared to the control. Both garcinol and pterostilbene significantly attenuated the protein expressions of PPAR gamma and C/EBP alpha during 3T3-L1 adipocyte differentiation. Moreover, garcinol and pterostilbene caused an inhibition of lipid accumulation in the 3T3-L1 adipocyte differentiation phase. Garcinol and pterostilbene also significantly up-regulated the gene expression of adiponectin as well as down-regulated the gene expressions of leptin, resistin, and fatty acid synthase (FAS) in 3T3-L1 adipocyte differentiation. In 3T3-L1 adipocytes, garcinol significantly down-regulated the protein expressions of PPAR gamma and FAS as well as up-regulated the protein expressions of adipose triglyceride lipase (ATGL) and adiponectin. Garcinol also significantly up-regulated the gene expression of adiponectin as well as down-regulated the gene expressions of leptin and FAS. These results suggest that garcinol and pterostilbene have anti-adipogenic effects on preadipocytes and adipocytes.en_US
dc.language.isoen_USzh_TW
dc.relationFood & Functionen_US
dc.relation.ispartofseriesFood & Function, Volume 3, Issue 1, Page(s) 49-57.en_US
dc.relation.urihttp://dx.doi.org/10.1039/c1fo10209een_US
dc.subjectconjugated linoleic-aciden_US
dc.subjectantioxidant activityen_US
dc.subjectadipose conversionen_US
dc.subjectmetabolic syndromeen_US
dc.subjectphenolic-acidsen_US
dc.subjectpre-adipocytesen_US
dc.subjectapoptosisen_US
dc.subjectadiponectinen_US
dc.subjectobesityen_US
dc.subjectsuppressionen_US
dc.titleInhibitory effects of garcinol and pterostilbene on cell proliferation and adipogenesis in 3T3-L1 cellsen_US
dc.typeJournal Articlezh_TW
dc.identifier.doi10.1039/c1fo10209ezh_TW
item.grantfulltextnone-
item.openairetypeJournal Article-
item.languageiso639-1en_US-
item.fulltextno fulltext-
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
Appears in Collections:食品暨應用生物科技學系
Show simple item record
 

Google ScholarTM

Check

Altmetric

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.