Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/62092
DC FieldValueLanguage
dc.contributor.authorShyu, M.H.en_US
dc.contributor.author顏國欽zh_TW
dc.contributor.authorKao, T.C.en_US
dc.contributor.authorYen, G.C.en_US
dc.date2008zh_TW
dc.date.accessioned2014-06-09T06:26:24Z-
dc.date.available2014-06-09T06:26:24Z-
dc.identifier.issn0278-6915zh_TW
dc.identifier.urihttp://hdl.handle.net/11455/62092-
dc.description.abstractIn this study, the protective effect of extract of Hsian-tsao (Mesona procumbens) (EHT) against liver fibrogenesis in carbon tetrachloride (CCl(4))-injured rats was evaluated. The inhibitory effect of oleanolic acid (OA) and Ursolic acid (UA), which are the active compounds in EHT, on the activation of hepatic stellate cells (HSC) was also determined. The results showed that EHT at a dosage of 1.2 g/kg of b.w. significantly reduced the liver injury induced by CCl(4) in rats. It also decreased the activity of serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) and the deposition of collagen in the liver. Oral administration of EHT reduced the levels of alpha-smooth muscle actin (alpha-SMA) and the activity of metalloproteinases (MMPs) in rats injured by treatment with CCl(4)- In addition, we performed experiments with the rat hepatic stellate cell line HSC-T6 in which we induced the expression of MMP-2 and alpha-SMA with phorbol-12-myristate-13-acetate (PMA). Treating these cells with OA (20 mu M) or UA (10 mu M) caused a decrease in the levels of both proteins. Taken together, our data indicate that EHT can efficiently inhibit CCl(4)-induced liver fibrosis in rats. EHT may therefore be a useful functional food for preventing liver fibrosis. (C) 2008 Elsevier Ltd. All rights reserved.en_US
dc.language.isoen_USzh_TW
dc.relationFood and Chemical Toxicologyen_US
dc.relation.ispartofseriesFood and Chemical Toxicology, Volume 46, Issue 12, Page(s) 3707-3713.en_US
dc.relation.urihttp://dx.doi.org/10.1016/j.fct.2008.09.051en_US
dc.subjectHsian-tsaoen_US
dc.subjectLiver fibrogenesisen_US
dc.subjectOleanolic aciden_US
dc.subjectUrsolic aciden_US
dc.subjectHepaticen_US
dc.subjectstellate cellen_US
dc.subjectoleanolic acid glycosidesen_US
dc.subjectursolic aciden_US
dc.subjectcarbon-tetrachlorideen_US
dc.subjectmatrixen_US
dc.subjectmetalloproteinasesen_US
dc.subjectdamageen_US
dc.subjectproliferationen_US
dc.subjectconstituentsen_US
dc.subjectmechanismsen_US
dc.subjectexpressionen_US
dc.subjectlipocytesen_US
dc.titleHsian-tsao (Mesona procumbens Heml.) prevents against rat liver fibrosis induced by CCl(4) via inhibition of hepatic stellate cells activationen_US
dc.typeJournal Articlezh_TW
dc.identifier.doi10.1016/j.fct.2008.09.051zh_TW
item.languageiso639-1en_US-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.openairetypeJournal Article-
item.fulltextno fulltext-
item.grantfulltextnone-
Appears in Collections:食品暨應用生物科技學系
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