Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/62111
標題: Effects of resveratrol and 4-hexylresorcinol on hydrogen peroxide-induced oxidative DNA damage in human lymphocytes
作者: Yen, G.C.
顏國欽
Duh, P.D.
Lin, C.W.
關鍵字: resveratrol;4-hexylresorcinol;antioxidant enzyme;DNA damage;lymphocyte;glutathione s-transferases;cancer;liver;cells;mice
Project: Free Radical Research
期刊/報告no:: Free Radical Research, Volume 37, Issue 5, Page(s) 509-514.
摘要: 
The protective effects of resveratrol and 4-hexylresorcinol against oxidative DNA damage in human lymphocytes induced by hydrogen peroxide were investigated. Resveratrol and 4-hexylresorcinol showed no cytotoxicity to human lymphocytes at the tested concentration (10-100 muM). In addition, DNA damage in human lymphocytes induced by H2O2 was inhibited by resveratrol and 4-hexylresorcinol. Resveratrol and 4-hexylresorcinol at concentrations of 10-100 muM induced an increase in glutathione (GSH) levels in a concentration-dependent manner. Moreover, these two compounds also induced activity of glutathione peroxidase (GPX) and glutathione reductase (GR). The activity of glutathione-S-transferase (GST) in human lymphocytes was induced by resveratrol. Resveratrol and 4-hexylresorcinol inhibited the activity of catalase (CAT). These data indicate that the inhibition of resveratrol and 4-hexylresorcinol on oxidative DNA damage in human lymphocytes induced by H2O2 might be attributed to increase levels of GSH and modulation of antioxidant enzymes (GPX, GR and GST).
URI: http://hdl.handle.net/11455/62111
ISSN: 1071-5762
DOI: 10.1080/1071576031000083099
Appears in Collections:食品暨應用生物科技學系

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