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|標題:||Anti-inflammatory Effects of the Roots of Alpinia pricei Hayata and Its Phenolic Compounds||作者:||Yu, Y.S.
|關鍵字:||Alpinia pricei Hayata;anti-inflammation;RAW 264.7 cells;lipopolysaccharide;pinocembrin;nitric-oxide synthase;nf-kappa-b;inducible cyclooxygenase;inflammatory mediators;oxidative stress;cells;diarylheptanoids;macrophages;officinarum;activation||Project:||Journal of Agricultural and Food Chemistry||期刊/報告no：:||Journal of Agricultural and Food Chemistry, Volume 57, Issue 17, Page(s) 7673-7680.||摘要:||
Alpinia pricei Hayata is cultivated throughout Asia and is an endemic plant in Taiwan. The leaf and root of this plant are used for traditional wrapping of food and as a cooking substitute for fresh ginger. The aim of this work was to study the in vitro anti-inflammatory effects of ethanol extracts from A. pricei Hayata (EEAP) and its phenolic compounds. High-performance liquid chromatography (HPLC) profiling indicated that EEAP contained caffeic acid, chlorogenic acid, ferulic acid, p-hydroxybenzoic acid, rutin, apigenin, curcumin and pinocembrin. EEAP and its phenolic compounds, apigenin, curcumin, and pinocembrin, inhibited lipopolysaccharide (LPS)-stimulated nitric oxide (NO) and prostaglandin E(2) (PGE(2)) production in RAW 264.7 cells. Furthermore, EEAP, apigenin, curcumin, and pinocembrin decreased LIPS-mediated induction of protein and mRNA expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in RAW 264.7 cells. In addition, EEAP and its major active compound pinocembrin inhibited LIPS-induced nuclear translocation of nuclear factor-kappa B (NF-kappa B) and NF-kappa B-mediated reporter gene expression. EEAP and pinocembrin also significantly inhibited LIPS-induced intracellular reactive oxygen species (ROS) production in RAW 264.7 cells. When these results are taken together, they indicate that EEAP and pinocembrin suppressed LPS-induced NO and PGE(2) production by inhibition of NF-kappa B nuclear translocation and ROS generation.
|Appears in Collections:||食品暨應用生物科技學系|
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