Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/62132
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dc.contributor.authorYeh, C.T.en_US
dc.contributor.author顏國欽zh_TW
dc.contributor.authorYen, G.C.en_US
dc.date2003zh_TW
dc.date.accessioned2014-06-09T06:26:27Z-
dc.date.available2014-06-09T06:26:27Z-
dc.identifier.issn0021-8561zh_TW
dc.identifier.urihttp://hdl.handle.net/11455/62132-
dc.description.abstractSulfate conjugation by phenolsulfotransferase (PST) enzyme is an important process in the detoxification of xenobiotics and endogenous compounds. There are two forms of PST that are specific for the sulfation of small phenols (PST-P) and monoamines (PST-M). Phenoilc acids have been reported to have important biological and pharmacological properties and may have benefits to human health. In the present study, human platelets were used as a model to investigate the influence of 13 phenolic acids on human PST activity and to evaluate the relationship to their antioxidant activity. The results showed that chlorogenic acid, syringic acid, protocatechuic acid, vanillic acid, sinapic acid, and caffeic acid significantly (p < 0.05) inhibited the activities of both forms of PST by 21-30% at a concentration of 6.7 muM. The activity of PST-P was enhanced (p < 0.05) by P-hydroxybenzoic acid, gallic acid, gentisic acid, o-coumaric acid, p-coumaric acid, and m-coumaric acid at a concentration of 6.7 muM, whereas the activity of PST-M was enhanced by gentisic acid, gallic acid, p-hydroxybenzoic acid, and ferulic acid. The phenolic acids exhibited antioxidant activity as determined by the oxygen radical absorbance capacity (ORAC) assay and Trolox equivalent antioxidant capacity (TEAC) assay, especially gallic acid, p-hydroxybenzoic acid, gentisic acid, and coumaric acid, which had strong activity. The overall effect of phenolic acids tested on the activity of PST-P and PST-M was well correlated to their antioxidant activity of ORAC value (r = 0.71, p < 0.01; and r = 0.66, p < 0.01). These observations suggest that antioxidant phenolic acids might alter sulfate conjugation.en_US
dc.language.isoen_USzh_TW
dc.relationJournal of Agricultural and Food Chemistryen_US
dc.relation.ispartofseriesJournal of Agricultural and Food Chemistry, Volume 51, Issue 5, Page(s) 1474-1479.en_US
dc.relation.urihttp://dx.doi.org/10.1021/jf0208132en_US
dc.subjectplateleten_US
dc.subjecthuman phenolsulfotransferasesen_US
dc.subjectphenolic acidsen_US
dc.subjectantioxidanten_US
dc.subjectactivityen_US
dc.subjecthuman sulfotransferasesen_US
dc.subjectcytosolic sulfotransferasesen_US
dc.subjectdna-damageen_US
dc.subjectsulfationen_US
dc.subjectcapacityen_US
dc.subjectpotenten_US
dc.subjectinhibitoren_US
dc.subjectmigraineen_US
dc.subjectplasmaen_US
dc.titleEffects of phenolic acids on human phenolsulfotransferases in relation to their antioxidant activityen_US
dc.typeJournal Articlezh_TW
dc.identifier.doi10.1021/jf0208132zh_TW
item.languageiso639-1en_US-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.openairetypeJournal Article-
item.fulltextno fulltext-
item.grantfulltextnone-
Appears in Collections:食品暨應用生物科技學系
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