Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/62134
DC FieldValueLanguage
dc.contributor.authorWeng, C.J.en_US
dc.contributor.author顏國欽zh_TW
dc.contributor.authorWu, C.F.en_US
dc.contributor.authorHuang, H.W.en_US
dc.contributor.authorWu, C.H.en_US
dc.contributor.authorHo, C.T.en_US
dc.contributor.authorYen, G.C.en_US
dc.date2010zh_TW
dc.date.accessioned2014-06-09T06:26:27Z-
dc.date.available2014-06-09T06:26:27Z-
dc.identifier.issn0021-8561zh_TW
dc.identifier.urihttp://hdl.handle.net/11455/62134-
dc.description.abstractHepatocellular carcinoma (HCC) is the most common type of liver cancer and is also highly metastatic. Metastasis is considered to be the major cause of death in cancer patients. Resveratrol (3,5,4'-trihydroxystilbene) and related analogues have been reported as candidates to prevent cancer growth and invasion. The bioactivity of resveratrol-related analogues could be altered due to the presence and positioning of methoxy groups on the basic resveratrol chemical structure. This study investigated the effects and mechanism of action of resveratrol and its methoxy analogues on invasion of human hepatocarcinoma cells. The migratory and invasive abilities of phorbol 12-myristate 13-acetate (PMA)-treated HepG2 and PMA-untreated Hep3B cells were both reduced in a dose-dependent manner by treatment with resveratrol and 3,5,4'-trimethoxy-trans-stilbene (MR-3). Upon incubation of PMA-treated HepG2 cells with resveratrol (0-50 mu M) or MR-3 (0-50 mu M), the MMP-9 activity decreased but TIMP-1 protein increased in a dose-dependent manner. With resveratrol (0-50 mu M) or MR-3 (0-1 mu M) treatment on PMA-untreated Hep3B cells, both of the MMP-9 and MMP-2 activities decreased but TIMP-2 protein increased in a dose-dependent manner. These results suggest that resveratrol and its related methoxy analogue MR-3 might exert anti-invasive activity against hepatoma cells through regulation of MMP-2, MMP-9, TIMP-1, and TIMP-2. Further analysis with semiquantitative RT-PCR showed that the regulation of MMP-9 and TIMP-2 expressions by resveratrol and MR-3 in hepatoma cells may be on the transcriptional level but on the translational or post-translational level for TIMP-1.en_US
dc.language.isoen_USzh_TW
dc.relationJournal of Agricultural and Food Chemistryen_US
dc.relation.ispartofseriesJournal of Agricultural and Food Chemistry, Volume 58, Issue 5, Page(s) 2886-2894.en_US
dc.relation.urihttp://dx.doi.org/10.1021/jf904182yen_US
dc.subjectInvasionen_US
dc.subjectMMPsen_US
dc.subjectMR-3en_US
dc.subjectresveratrolen_US
dc.subjectTIMPsen_US
dc.subjectuPAen_US
dc.subjectbreast-cancer cellsen_US
dc.subjecthuman cytochrome p4501b1en_US
dc.subjectmatrix-metalloproteinase-9 expressionen_US
dc.subjectsignal-transductionen_US
dc.subjectmultiple-myelomaen_US
dc.subjectstilbene analogsen_US
dc.subjecttissue inhibitoren_US
dc.subjectcarcinoma cellsen_US
dc.subjectin-vivoen_US
dc.subjectkappa-ben_US
dc.titleEvaluation of Anti-invasion Effect of Resveratrol and Related Methoxy Analogues on Human Hepatocarcinoma Cellsen_US
dc.typeJournal Articlezh_TW
dc.identifier.doi10.1021/jf904182yzh_TW
item.languageiso639-1en_US-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.openairetypeJournal Article-
item.fulltextno fulltext-
item.grantfulltextnone-
Appears in Collections:食品暨應用生物科技學系
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