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標題: Glycyrrhizic Acid and 18 beta-Glycyrrhetinic Acid Inhibit Inflammation via PI3K/Akt/GSK3 beta Signaling and Glucocorticoid Receptor Activation
作者: Kao, T.C.
Shyu, M.H.
Yen, G.C.
關鍵字: Glycyrrhizic acid;18 beta-glycyrrhetinic acid;PI3K/Akt signaling;pathway;GSK3 beta phosphotylation;glucocorticold receptor;anti-inflammation;obstructive pulmonary-disease;phosphoinositide 3-kinase;kappa-b;licorice;macrophages;sensitivity;responses;pathway;asthma;injury
Project: Journal of Agricultural and Food Chemistry
期刊/報告no:: Journal of Agricultural and Food Chemistry, Volume 58, Issue 15, Page(s) 8623-8629.
Many lung-related diseases, such as asthma and chronic obstructive pulmonary disease, are initiated by airway inflammation, and several studies indicate that glycyrrhizic acid (GA) alleviates inflammatory lung disease. We previously showed that GA and 18 beta-glycyrrhetinic acid (18 beta GA), found in licorice, can act as neuroprotective agents by promoting downstream PI3K/Akt signaling. In this study, we investigate the effects of GA and 18 beta GA on inflammation. We show that both GA and 18 beta GA reduce inflammatory cytokine production and its resulting anti-inflammation. GA acts via PI3K/Akt/GSK3 beta to reduce cytokine production, while 18 beta GA leads to the dissociation of a glucocorticoid receptor (GR)-HSP90 complex to block inflammation. Our data suggest that GA and 18 beta GA display anti-inflammatory activities but inhibit inflammation via different mechanisms. We propose that GA and 18 beta GA may be valuable biological inhibitors of lung inflammation. Interestingly, these data may explain why licorice is frequently used to treat inflammatory disease and it might be a promising nutraceutical for remedying inflammation.
ISSN: 0021-8561
DOI: 10.1021/jf101841r
Appears in Collections:食品暨應用生物科技學系

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