Please use this identifier to cite or link to this item:
標題: Phenolic Compounds Rutin and o-Coumaric Acid Ameliorate Obesity Induced by High-Fat Diet in Rats
作者: Hsu, C.L.
Wu, C.H.
Huang, S.L.
Yen, G.C.
關鍵字: Rutin;o-coumaric acid;dyslipidemia;hepatosteatosis;oxidative stress;oxidative stress;antioxidant status;3t3-l1 cells;inhibition;disease;mice;adipogenesis;prevention;induction;apoptosis
Project: Journal of Agricultural and Food Chemistry
期刊/報告no:: Journal of Agricultural and Food Chemistry, Volume 57, Issue 2, Page(s) 425-431.
Dietary fat is one of the most important environmental factors associated with the incidence of cardiovascular diseases. In this study, the antiobesity effects of rutin (R) and o-coumaric acid (oCA) were investigated. Wistar rats were divided into normal and obese groups, and obese rats were prefed a high-fat diet (HFD) containing 40% beef tallow for 4 weeks. Then, R and oCA were given as a supplement to obese rats at doses of 50 and 100 mg/kg, respectively, for a period of 8 weeks. The results showed that body, liver organ, and adipose tissue weights of peritoneal and epididymal fat pads in the HFD+ R and HFD+oCA groups were significantly decreased as compared to those in the HFD group. Serum lipid profiles, insulin, and leptin were significantly decreased in the HFD+ R (high dose, HD) and HFD+oCA (HD) groups as compared to those in the HFD group. Hepatic triacylglycerol and cholesterol levels were significantly decreased in the HFD+ R (HD) and HFD+oCA (HD) groups as compared to those in the HFD group. Moreover, the consumption of R and oCA reduced oxidative stress and glutathione disulfide (GSSG) content, and enhanced the levels of glutathione (GSH), GSH peroxidase (GPx), GSH reductase (GRd), and GSH S-transferase (GST) in the hepatic tissue of rats with HFD-induced obesity. These results demonstrate that intake of R and oCA can be beneficial for the suppression of high-fat-diet-induced dyslipidemia, hepatosteatosis, and oxidative stress in rats.
ISSN: 0021-8561
DOI: 10.1021/if802715t
Appears in Collections:食品暨應用生物科技學系

Show full item record

Google ScholarTM




Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.