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|標題:||Effect of sulfite-treated daylily (Hemerocallis fulva L.) flower on the production of nitric oxide and DNA damage in macrophages||作者:||Chen, H.Y.
|關鍵字:||daylily flower;Hemerocallis fulva L.;nitric oxide;sulfur dioxide;DNA;damage;comet assay;cell-line;flavonoids;peroxynitrite;inhibition;vegetables;chemistry;toxicity;kwanso||Project:||Journal of Food and Drug Analysis||期刊/報告no：:||Journal of Food and Drug Analysis, Volume 15, Issue 1, Page(s) 63-70.||摘要:||
The inhibitory effect of fresh or dried daylilies extract on the generation of nitric oxide, and the effects of sulfur dioxide in dried daylily on nitric oxide production and DNA damage in Raw 264.7 macrophages were examined. The extracts from sulfite-treated and untreated dried daylily flowers exhibited stronger scavenging effects on nitric oxide production by sodium nitroprusside (SNP) than that of fresh flower. Fresh and untreated dried daylily flowers exhibited strong inhibitory effect on nitric oxide induced by lipopolysaccharide (LPS) in macrophages, but the sulfite-treated dried daylily did not. The scavenging effect of sulfite on nitric oxide production by SNP was dose-dependent, and sulfite also exhibited low inhibitory effect on nitric oxide induced by LPS in macrophages. Sodium hydrogen sulfite also slightly induced DNA damage in macrophages. Although sulfur dioxide in dried flowers is volatilized during heating, its residual adverse effects should still be concerned.
|Appears in Collections:||食品暨應用生物科技學系|
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