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|標題:||Inducing gene expression of cardiac antioxidant enzymes by dietary phenolic acids in rats||作者:||Yeh, C.T.
|關鍵字:||Cardioprotection;Heart;Antioxidant enzymes;Heme oxygenase-1;Antioxidant capacity;drug-metabolizing-enzymes;heme oxygenase-1 gene;phase-ii enzymes;transcription factor;gallic acid;nrf2;induction;pathway;injury;heart||Project:||Journal of Nutritional Biochemistry||期刊/報告no：:||Journal of Nutritional Biochemistry, Volume 20, Issue 3, Page(s) 163-171.||摘要:||
An increase in oxidative stress is suggested to be intimately involved in the pathogenesis of heart failure. Phenolic acids are widespread in plant foods; they contain important biological and pharmacological properties. This study evaluated the role of phenolic acids on the expression of antioxidant enzymes in the heart of male Sprugue-Dawley rats. Gallic acid, ferulic acid and p-coumaric acid at a dosage of 100 mg kg (1) body weight significantly increased the activities of cardiac superoxide dismutase, glutathione peroxidase (GPx) and catalase (CAT) as compared with control rats (P<.05). The changes in cardiac CuZnSOD, GPx and CAT mRNA levels induced by phenolic acids were similar to those noted in the enzyme activity levels. A significant (P<.05) increase in the GSII/GSSG ratio was observed in the heart of phenolic acid-treated rats. The heart homogenates obtained from rats that were administered phenolic acids displayed significant (P<.05) increases in capacity for oxygen radical absorbance compared with control rats. Immunoblot analysis revealed the increased cardiac total level of Nrf2 in phenolic acid-treated rats. Interestingly, phenolic acid-mediated antioxidant enzyme expression was accompanied by tip-regulation of heme oxygenase-1. This study demonstrates that antioxidant enzymes in rat cardiac tissue can be significantly induced by phenolic acids following oral administration. (C) 2009 Elsevier Inc. All rights reserved.
|Appears in Collections:||食品暨應用生物科技學系|
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