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標題: Inducing gene expression of cardiac antioxidant enzymes by dietary phenolic acids in rats
作者: Yeh, C.T.
Ching, L.C.
Yen, G.C.
關鍵字: Cardioprotection;Heart;Antioxidant enzymes;Heme oxygenase-1;Antioxidant capacity;drug-metabolizing-enzymes;heme oxygenase-1 gene;phase-ii enzymes;transcription factor;gallic acid;nrf2;induction;pathway;injury;heart
Project: Journal of Nutritional Biochemistry
期刊/報告no:: Journal of Nutritional Biochemistry, Volume 20, Issue 3, Page(s) 163-171.
An increase in oxidative stress is suggested to be intimately involved in the pathogenesis of heart failure. Phenolic acids are widespread in plant foods; they contain important biological and pharmacological properties. This study evaluated the role of phenolic acids on the expression of antioxidant enzymes in the heart of male Sprugue-Dawley rats. Gallic acid, ferulic acid and p-coumaric acid at a dosage of 100 mg kg (1) body weight significantly increased the activities of cardiac superoxide dismutase, glutathione peroxidase (GPx) and catalase (CAT) as compared with control rats (P<.05). The changes in cardiac CuZnSOD, GPx and CAT mRNA levels induced by phenolic acids were similar to those noted in the enzyme activity levels. A significant (P<.05) increase in the GSII/GSSG ratio was observed in the heart of phenolic acid-treated rats. The heart homogenates obtained from rats that were administered phenolic acids displayed significant (P<.05) increases in capacity for oxygen radical absorbance compared with control rats. Immunoblot analysis revealed the increased cardiac total level of Nrf2 in phenolic acid-treated rats. Interestingly, phenolic acid-mediated antioxidant enzyme expression was accompanied by tip-regulation of heme oxygenase-1. This study demonstrates that antioxidant enzymes in rat cardiac tissue can be significantly induced by phenolic acids following oral administration. (C) 2009 Elsevier Inc. All rights reserved.
ISSN: 0955-2863
DOI: 10.1016/j.jnutbio.2008.01.005
Appears in Collections:食品暨應用生物科技學系

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