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|標題:||Modulation of hepatic phase II phenol sulfotransferase and antioxidant status by phenolic acids in rats||作者:||Yeh, C.T.
|關鍵字:||phenolic acids;phenol sulfotransferase;antioxidant capacity;bioavailabifity;Sprague-Dawley rat;ferulic acid;hydroxysteroid sulfotransferase;gallic acid;liver;absorption;metabolites;enzymes;plasma;(-)-epicatechin;consumption||Project:||Journal of Nutritional Biochemistry||期刊/報告no：:||Journal of Nutritional Biochemistry, Volume 17, Issue 8, Page(s) 561-569.||摘要:||
Phenolic acids have significant biological and pharmacological properties and some have demonstrated remarkable ability to alter sulfate conjugation. However, the modulatory effects of phenolic acids on phenol sulfotransferases (PSTs) in vivo have not been described. The present investigation evaluates the role of phenolic acid on the expression of PSTs in male Sprague-Dawley rat liver. According to the results, gentisic acid, gallic acid and p-coumaric acid in a dosage of 100 mg/kg of body weight for 14 consecutive days significantly increased Morin PST (PST-P) activity as compared with that of the control rats (P <.05), whereas the activity of M-form PST (PST-M) in rats that received gallic acid and p-coumaric acid were also significantly (P <.05) higher than in the control rats. Reverse transcriptase-polymerase chain reaction results indicated that the changes in both PST-P and PST-M mRNA levels by phenolic acids were similar to those noted in the enzyme activity levels. The plasma obtained from phenolic acid-administered rats had significantly (P <.05) increased oxygen radical absorbance capacity (ORAC(ROO)(.)) values than that from control rats. lit a bioavailability study, following oral administration of gallic acid and p-coumaric acid, the phenolic acids were detected in the plasma, and the C a values after 2.0-h administration were 665 +/- 23 and 550 33 nmol/L, respectively. There was a significant correlation between the activity of both forms of PSTs and the antioxidant capacity of ORACROO. value by phenolic acids (r=.74, P <.05 and r=.77, P <.05). These data suggest that phenolic acids might alter sulfate conjugation and antioxidant capacity in living systems. (c) 2006 Elsevier Inc. All rights reserved.
|Appears in Collections:||食品暨應用生物科技學系|
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