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標題: The anti-invasive effect of lucidenic acids isolated from a new Ganoderma lucidum strain
作者: Weng, C.J.
Chau, C.F.
Chen, K.D.
Chen, D.H.
Yen, G.C.
關鍵字: anti-invasion;Ganoderma lucidum;HepG(2) cells;lucidenic acid;MMP-9;activity;cancer;antitumor;reishi
Project: Molecular Nutrition & Food Research
期刊/報告no:: Molecular Nutrition & Food Research, Volume 51, Issue 12, Page(s) 1472-1477.
Ganoderma lucidum is a well-known mushroom with various pharmacological effects that has been used for health and longevity purposes. The objective of this study was to investigate the anti-invasive effect of lucidenic acids isolated from a new G. lucidum strain (YK-02) against human hepatoma carcinoma (HepG(2)) cells. Triterpenoid components in the ethanol extract of G. lucidum (YK-02) were separated by means of a semi-preparative R-P HPLC. Four major peaks were separated and crystallized from triterpenoids fraction, and were identified as lucidenic acids A, B, C, and N according to their spectroscopic values of H-1 NMR and MS. Treatment of the lucidenic acids (50 mu M) in the presence of 200 nM phorbol 12-myristate 13-acetate (PMA) after 24 It of incubation all resulted in significant inhibitory effects on PMA-induced MMP-9 activity and invasion of HepG2 cells. The results indicate that the lucidenic acids isolated from G. lucidum (YK-02) are anti-invasive bioactive components on hepatoma cells.
ISSN: 1613-4125
DOI: 10.1002/mnfr.200700155
Appears in Collections:食品暨應用生物科技學系

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