Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/62207
DC FieldValueLanguage
dc.contributor.authorChen, Y.H.en_US
dc.contributor.author胡淼琳zh_TW
dc.contributor.authorWang, M.F.en_US
dc.contributor.authorLiao, J.W.en_US
dc.contributor.authorChang, S.P.en_US
dc.contributor.authorHu, M.L.en_US
dc.contributor.author廖俊旺zh_TW
dc.date2008zh_TW
dc.date.accessioned2014-06-09T06:26:35Z-
dc.date.available2014-06-09T06:26:35Z-
dc.identifier.issn0951-6433zh_TW
dc.identifier.urihttp://hdl.handle.net/11455/62207-
dc.description.abstractThe deleterious effects of ethanol in senescence-accelerated prone 8 mice (SAMP8) and the protective role of nicotinamide (NAM) against ethanol-induced liver injury were examined. The mice were orally administered 2 g ethanol/kg BW and 200 mg or 500 mg NAM/kg BW three times/week for 10 weeks. Results showed that ethanol elevated activity of alanine aminotransferase (ALT) significantly. Ethanol also enhanced the formation of malondialdehyde (MDA) and protein carbonyls in the liver, whereas ethanol treatment resulted in significantly lower activity of hepatic glutathione peroxidase (GPx), catalase and superoxide dismutase (SOD). Hematoxylin and eosin staining indicated moderate to severe fatty infiltration but not fibrosis. Administration of high NAM (500 mg/kg BW) led to markedly decreased levels of hepatic MDA, protein carbonyls, fatty infiltration and the activity of ALT, and increased activity of GPx, catalase and SOD in the ethanol-fed group. Thus, using SAMP8 as animal model for ethanol-induced liver injury in the aged mice, this study demonstrates that NAM is effective in protecting such damage.en_US
dc.language.isoen_USzh_TW
dc.relationBiofactorsen_US
dc.relation.ispartofseriesBiofactors, Volume 34, Issue 2, Page(s) 97-107.en_US
dc.subjectSenescence-accelerate miceen_US
dc.subjectoxidative stressen_US
dc.subjectnicotinamideen_US
dc.subjectalcohol-induced liver injuryen_US
dc.subjectinduced oxidative stressen_US
dc.subjectethanol-consumptionen_US
dc.subjectprotein oxidationen_US
dc.subjectn-acetylcysteineen_US
dc.subjectmouse-brainen_US
dc.subjectrat-liveren_US
dc.subjectantioxidanten_US
dc.subjectaciden_US
dc.subjectexpressionen_US
dc.subjectdamageen_US
dc.titleBeneficial effects of nicotinamide on alcohol-induced liver injury in senescence-accelerated miceen_US
dc.typeJournal Articlezh_TW
item.cerifentitytypePublications-
item.grantfulltextnone-
item.languageiso639-1en_US-
item.fulltextno fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeJournal Article-
Appears in Collections:食品暨應用生物科技學系
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