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標題: Product Selectivity and Optimization of Lipase-Catalyzed 1,3-Propylene Glycol Esters by Mixture Design and RSM
作者: Chen, Hsiao-Ching
Kuo, Chia-Hung
Tsai, Wei-Chuan
Chung, Yi-Lin
Chiang, Wen-Dee
Chieh-Ming, J.Chang
Liu, Yung-Chuan
Shieh, Chwen-Jen
關鍵字: Ester;Lipase;Mixture design;Optimization;Propylene glycol;RSM
Project: J Am Oil Chem Soc, Volume 89, Page(s) 231–241.
Propylene glycol mono- (PGM) and diesters
(PGD) are widely used as emulsifiers in food and pharmaceutical
industry. Solvent engineering was applied to
determine the optimum solvent mixtures for the lipasecatalyzed
synthesis of 1,3-PGM and 1,3-PGD. After 24 h
reaction, the results showed that the molar production of
1,3-PGM was 75% under pure 2M2B (2-methyl-2-butanol)
system, whereas 1,3-PGD was preferred to produce in
binary mixture system (n-hexane: octane 1:1) with 55% of
molar production. Furthermore, the reaction parameters
that affect esterification of 1,3-PGD using oleic acid as acyl
donor in optimum cosolvent environment were evaluated
by response surface methodology (RSM). The reaction
temperature and reaction time were the most important
parameters. Based on a ridge max analysis, the optimum
conditions for 1,3-PGD synthesis were predicted to consist
of a reaction time of 40.6 min, a temperature of 59 C,
an enzyme amount of 70.4%, a substrate molar ratio
(1,3-propylene glycol/oleic acid) of 1:2.7 and an enzyme
pretreatment pH of 6.4 on percentage of molar production
of 1,3-PGD of 43.3 � 4.2%.
DOI: 10.1007/s11746-011-1914-9
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