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標題: 利用數學模組探討台灣抗氟奎林之沙門氏菌在豬隻及人類間的傳播
Modeling the Transmission Dynamics of Fluoroquinolone-Resistant Salmonella between Pigs and Humans in Taiwan
作者: 黎樂恩
Ian, Lai Lok
關鍵字: mathematical model;數學模組;fluoroquinolones;Salmonella;pigs;humans;氟奎林;沙門氏菌;豬;人類
出版社: 微生物暨公共衛生學研究所
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The use of antibiotics is known to promote development of antibiotic-resistant (AR) bacteria either in animals or humans. Through consumption or handling of contaminated meat, certain AR bacteria in humans have been suspected to be from animal sources. However, as current studies relevant to this issue are mainly based on cross-sectional investigations, such an impact cannot be reasonably evaluated. In this study, a mathematical model consisting of a dynamic animal-and-human model was constructed to explore the transmission dynamics of FQR Salmonella Choleraesuis in pigs and humans. Prevalence of FQR S. Choleraesuis in animals and humans over time were simulated by a set of coupled differential equations. Our results indicate that the prevalence of FQR S. Choleraesuis in humans is strongly affected by antibiotic prescription in humans. That is, more fluorquinolones used in humans can hasten and amplify the occurrence of FQR S. Choleraesuis in humans. However, using fluoroquinolones in pigs can only speed up the appearance of FQR S. Choleraesuis in humans, but may not affect their long-term prevalence. Furthermore, more exposure sources of FQR S. Choleraesuis in humans, such as improper cooking or handling of contaminated meat, will increase the risk for the onset of FQR S. Choleraesuis and their equilibrium prevalence. To combat FQR S. Choleraesuis infection, our model suggests that a decrease in antibiotic use in animal husbandry alone will have little effect on equilibrium prevalence of resistant bacteria among humans. Substantial efforts must be made to avoid unnecessary use of antibiotics in humans.
其他識別: U0005-3006201111545400
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