Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/66368
標題: 利用數學模組探討台灣抗氟奎林之沙門氏菌在豬隻及人類間的傳播
Modeling the Transmission Dynamics of Fluoroquinolone-Resistant Salmonella between Pigs and Humans in Taiwan
作者: 黎樂恩
Ian, Lai Lok
關鍵字: mathematical model;數學模組;fluoroquinolones;Salmonella;pigs;humans;氟奎林;沙門氏菌;豬;人類
出版社: 微生物暨公共衛生學研究所
引用: 呂旭峰、廖容琪、劉啟明。2008。與公共衛生相關之常見重要食品致病細菌。感染控制雜誌,第十八卷第二期,81-91。 張上淳、陳宜君、賴美淑、張鴻仁。2006。台灣住院病人2000-2004年抗生素使用之情形。感染控制雜誌,第十六卷第四期,205-218。 Aarestrup, F.M., Carstensen, B., 1998, Effect of tylosin used as a growth promoter on the occurrence of macrolide-resistant enterococci and staphylococci in pigs. Microb Drug Resist 4, 307-312. Aarestrup, F.M., Kruse, H., Tast, E., Hammerum, A.M., Jensen, L.B., 2000, Associations between the use of antimicrobial agents for growth promotion and the occurrence of resistance among Enterococcus faecium from broilers and pigs in Denmark, Finland, and Norway. Microb Drug Resist 6, 63-70. Ackman, D.M., Drabkin, P., Birkhead, G., Cieslak, P., 1995, Reptile-associated salmonellosis in New York State. Pediatr Infect Dis J 14, 955-959. Asai, T., Esaki, H., Kojima, A., Ishihara, K., Tamura, Y., Takahashi, T., 2006, Antimicrobial resistance in Salmonella isolates from apparently healthy food-producing animal from 2000 to 2003: the first stage of Japanese veterinary antimicrobial resistance monitoring (JVARM). J Vet Med Sci 68, 881-884. Aserkoff, B., Bennett, J.V., 1969, Effect of antibiotic therapy in acute salmonellosis on the fecal excretion of Salmonellae. N Engl J Med 281, 636-640. Austin, D.J., Bonten, M.J., Weinstein, R.A., Slaughter, S., Anderson, R.M., 1999a, Vancomycin-resistant enterococci in intensive-care hospital settings: transmission dynamics, persistence, and the impact of infection control programs. Proc Natl Acad Sci U S A 96, 6908-6913. Austin, D.J., Kristinsson, K.G., Anderson, R.M., 1999b, The relationship between the volume of antimicrobial consumption in human communities and the frequency of resistance. Proc Natl Acad Sci U S A 96, 1152-1156. Bangtrakulnonth, A., Pornruangwong, S., Kusum, M., Damrongwatanapokin, T., Saitanu, K., 1995, Prevalence of Salmonella in humans during 1988-1993. . Southeast Asian J. Trop. Med Pub Health 26, 52-53. Barrell, R.A., 1987, Isolations of Salmonellas from humans and foods in the Manchester area: 1981-1985. Epidemiol Infect 98, 277-284. Barton, M.D., 2000, Antibiotic use in animal feed and its impact on human health. Nutr Res Rev 13, 279-299. Barza, M., Travers, K., 2002, Excess infections due to antimicrobial resistance: the "Attributable Fraction". Clin Infect Dis 34 Suppl 3, S126-130. Bauer-Garland, J., Frye, J.G., Gray, J.T., Berrang, M.E., Harrison, M.A., Fedorka-Cray, P.J., 2006, Transmission of Salmonella enterica serotype Typhimurium in poultry with and without antimicrobial selective pressure. J Appl Microbiol 101, 1301-1308. Belloc, C., Lam, D.N., Pellerin, J.L., Beaudeau, F., Laval, A., 2005, Effect of quinolone treatment on selection and persistence of quinolone-resistant Escherichia coli in swine faecal flora. J Appl Microbiol 99, 954-959. Belongia, E.A., Schwartz, B., 1998, Strategies for promoting judicious use of antibiotics by doctors and patients. BMJ 317, 668-671. Berends, B.R., Van Knapen, F., Mossel, D.A., Burt, S.A., Snijders, J.M., 1998, Impact on human health of Salmonella spp. on pork in The Netherlands and the anticipated effects of some currently proposed control strategies. Int J Food Microbiol 44, 219-229. Blower, S.M., Small, P.M., Hopewell, P.C., 1996, Control strategies for tuberculosis epidemics: new models for old problems. Science 273, 497-500. Borch, E., Nesbakken, T., Christensen, H., 1996, Hazard identification in swine slaughter with respect to foodborne bacteria. Int J Food Microbiol 30, 9-25. Brorsen, B.W., Lehenbauer, T., Ji, D., Connor, J., 2002, Economic impacts of banning subtherapeutic use of antibiotics in swine production. J Agr Appl Econ 34, 489-500. Butzler, J.P., 2004, Campylobacter, from obscurity to celebrity. Clin Microbiol Infect 10, 868-876. Casewell, M., Friis, C., Marco, E., McMullin, P., Phillips, I., 2003, The European ban on growth-promoting antibiotics and emerging consequences for human and animal health. J Antimicrob Chemother 52, 159-161. Chang, C.C., Lin, Y.H., Chang, C.F., Yeh, K.S., Chiu, C.H., Chu, C., Chien, M.S., Hsu, Y.M., Tsai, L.S., Chiou, C.S., 2005, Epidemiologic relationship between fluoroquinolone-resistant Salmonella enterica Serovar Choleraesuis strains isolated from humans and pigs in Taiwan (1997 to 2002). J Clin Microbiol 43, 2798-2804. Chang, S.C., Chen, Y.C., Hu, O.Y., 2001, Antibiotic use in public hospitals in Taiwan after the implementation of National Health Insurance. J Formos Med Assoc 100, 155-161. Chen, Y.H., Chen, T.P., Tsai, J.J., Hwang, K.P., Lu, P.L., Cheng, H.H., Peng, C.F., 1999, Epidemiological study of human salmonellosis during 1991-1996 in southern Taiwan. Kaohsiung J Med Sci 15, 127-136. Chiu, C.H., Lin, T.Y., Ou, J.T., 1999, Predictors for extraintestinal infection of non-typhoidal Salmonella in patients without AIDS. Int J Clin Pract 53, 161-164. Chiu, C.H., Su, L.H., Hung, C.C., Chen, K.L., Chu, C., 2004, Prevalence and antimicrobial susceptibility of serogroup D nontyphoidal Salmonella in a university hospital in Taiwan. J Clin Microbiol 42, 415-417. Chiu, C.H., Wu, T.L., Su, L.H., Chu, C., Chia, J.H., Kuo, A.J., Chien, M.S., Lin, T.Y., 2002, The emergence in Taiwan of fluoroquinolone resistance in Salmonella enterica serotype choleraesuis. N Engl J Med 346, 413-419. Christie, P.J., Davidson, J.N., Novick, R.P., Dunny, G.M., 1983, Effects of tylosin feeding on the antibiotic resistance of selected gram-positive bacteria in pigs. Am J Vet Res 44, 126-128. Cohen, J.I., Bartlett, J.A., Corey, G.R., 1987, Extra-intestinal manifestations of Salmonella infections. Medicine (Baltimore) 66, 349-388. Cox, N.A., Berrang, M.E., Cason, J.A., 2000, Salmonella penetration of egg shells and proliferation in broiler hatching eggs--a review. Poult Sci 79, 1571-1574. Cui, S., Ge, B., Zheng, J., Meng, J., 2005, Prevalence and antimicrobial resistance of Campylobacter spp. and Salmonella serovars in organic chickens from Maryland retail stores. Appl Environ Microbiol 71, 4108-4111. D''Aoust, J.Y., 1991, Pathogenicity of foodborne Salmonella. Int J Food Microbiol 12, 17-40. Datta, N., 1962, Transmissible drug resistance in an epidemic strain of Salmonella typhimurium. J Hyg (Lond) 60, 301-310. Delsol, A.A., Woodward, M.J., Roe, J.M., 2004, Effect of a 5 day enrofloxacin treatment on Salmonella enterica serotype Typhimurium DT104 in the pig. J Antimicrob Chemother 53, 396-398. Dietz, K., Heesterbeek, J.A., 2002, Daniel Bernoulli''s epidemiological model revisited. Math Biosci 180, 1-21. Endtz, H.P., Ruijs, G.J., van Klingeren, B., Jansen, W.H., van der Reyden, T., Mouton, R.P., 1991, Quinolone resistance in campylobacter isolated from man and poultry following the introduction of fluoroquinolones in veterinary medicine. J Antimicrob Chemother 27, 199-208. Engberg, J., Aarestrup, F.M., Taylor, D.E., Gerner-Smidt, P., Nachamkin, I., 2001, Quinolone and macrolide resistance in Campylobacter jejuni and C. coli: resistance mechanisms and trends in human isolates. Emerg Infect Dis 7, 24-34. Esaki, H., Morioka, A., Ishihara, K., Kojima, A., Shiroki, S., Tamura, Y., Takahashi, T., 2004, Antimicrobial susceptibility of Salmonella isolated from cattle, swine and poultry (2001-2002): report from the Japanese Veterinary Antimicrobial Resistance Monitoring Program. J Antimicrob Chemother 53, 266-270. F, L.P., Wierup, M., 2006, Salmonella contamination: a significant challenge to the global marketing of animal food products. Rev Sci Tech 25, 541-554. Ferber, D., 2003, Antibiotic resistance. WHO advises kicking the livestock antibiotic habit. Science 301, 1027. Foley, S.L., Lynne, A.M., 2008, Food animal-associated Salmonella challenges: pathogenicity and antimicrobial resistance. J Anim Sci 86, E173-187. Gaudreau, C., Gilbert, H., 2003, Antimicrobial resistance of Campylobacter jejuni subsp. jejuni strains isolated from humans in 1998 to 2001 in Montreal, Canada. Antimicrob Agents Chemother 47, 2027-2029. Gomez, T.M., Motarjemi, Y., Miyagawa, S., Kaferstein, F.K., Stohr, K., 1997, Foodborne salmonellosis. World Health Stat Q 50, 81-89. Grassly, N.C., Fraser, C., 2008, Mathematical models of infectious disease transmission. Nat Rev Microbiol 6, 477-487. Gray, J.T., Fedorka-Cray, P.J., 2001, Survival and infectivity of Salmonella choleraesuis in swine feces. J Food Prot 64, 945-949. Gray, J.T., Fedorka-Cray, P.J., Stabel, T.J., Ackermann, M.R., 1995, Influence of inoculation route on the carrier state of Salmonella choleraesuis in swine. Vet Microbiol 47, 43-59. Gray, J.T., Fedorka-Cray, P.J., Stabel, T.J., Kramer, T.T., 1996, Natural transmission of Salmonella choleraesuis in swine. Appl Environ Microbiol 62, 141-146. Guerri Santos, M.L., Rotger, R., 2004, [Change in resistance to quinolones and betalactams in different serogroups of Salmonella during the last decade in a Madrid hospital]. Rev Esp Quimioter 17, 37-43. Hart, C.A., Kariuki, S., 1998, Antimicrobial resistance in developing countries. BMJ 317, 647-650. Hayes, D.J., Jensen, H.H., 2003, Lessons from the Danish ban on feed-grade antibiotics. Center for Agricultural and Rural Development, Iowa State University, Ames. http://www.card.iastate.edu/public-cations/synopsis.aspx?id=484 Briefing Paper, 03-BP 41. Helms, M., Simonsen, J., Molbak, K., 2004, Quinolone resistance is associated with increased risk of invasive illness or death during infection with Salmonella serotype Typhimurium. J Infect Dis 190, 1652-1654. Hill, A., England, T., Snary, E., Cook, A., Kelly, L., Evans, S., Wooldridge, M., 2003, A "farm-to-consumption" risk assessment for the adverse effects to human health of Salmonella Typhimurium in pigs. Proceedings of the 10th International Symposium on Veterinary Epidemiology and Economics. Hinton, M., Hampson, D.J., Hampson, E., Linton, A.H., 1985, The effects of oxytetracycline on the intestinal Escherichia coli flora of newly weaned pigs. J Hyg (Lond) 95, 77-85. Holmberg, S.D., Solomon, S.L., Blake, P.A., 1987, Health and economic impacts of antimicrobial resistance. Rev Infect Dis 9, 1065-1078. Hooper, D.C., 2001, Emerging mechanisms of fluoroquinolone resistance. Emerg Infect Dis 7, 337-341. Hsueh, P.R., Teng, L.J., Tseng, S.P., Chang, C.F., Wan, J.H., Yan, J.J., Lee, C.M., Chuang, Y.C., Huang, W.K., Yang, D., Shyr, J.M., Yu, K.W., Wang, L.S., Lu, J.J., Ko, W.C., Wu, J.J., Chang, F.Y., Yang, Y.C., Lau, Y.J., Liu, Y.C., Liu, C.Y., Ho, S.W., Luh, K.T., 2004, Ciprofloxacin-resistant Salmonella enterica Typhimurium and Choleraesuis from pigs to humans, Taiwan. Emerg Infect Dis 10, 60-68. Jackson, C.R., Fedorka-Cray, P.J., Jackson-Hall, M.C., Hiott, L.M., 2005, Effect of media, temperature and culture conditions on the species population and antibiotic resistance of enterococci from broiler chickens. Lett Appl Microbiol 41, 262-268. Jong, M.C.M.d., 1995, Mathematical modelling in veterinary epidemiology: why model building is important Prev Vet Med 25, 189-193. Kaukas, A., Hinton, M., Linton, A.H., 1987, The effect of ampicillin and tylosin on the faecal enterococci of healthy young chickens. J Appl Bacteriol 62, 441-447. Kermack, W.O., McKendrick, A.G., 1927, A Contribution to the Mathematical Theory of Epidemics. Proc. Roy. Soc. Lond. A 115, 700-721. Khachatourians, G.G., 1998, Agricultural use of antibiotics and the evolution and transfer of antibiotic-resistant bacteria. CMAJ 159, 1129-1136. Khakhria, R., Johnson, W., 1995, Prevalence of Salmonella serotypes and phage types in Canada. Southeast Asian J Trop Med Public Health 26, 42-44. Klare, I., Badstubner, D., Konstabel, C., Bohme, G., Claus, H., Witte, W., 1999, Decreased incidence of VanA-type vancomycin-resistant enterococci isolated from poultry meat and from fecal samples of humans in the community after discontinuation of avoparcin usage in animal husbandry. Microb Drug Resist 5, 45-52. Lee, L.A., Puhr, N.D., Maloney, E.K., Bean, N.H., Tauxe, R.V., 1994, Increase in antimicrobial-resistant Salmonella infections in the United States, 1989-1990. J Infect Dis 170, 128-134. Levin, B.R., Lipsitch, M., Bonhoeffer, S., 1999, Population biology, evolution, and infectious disease: convergence and synthesis. Science 283, 806-809. Lipsitch, M., Levin, B.R., 1997, The population dynamics of antimicrobial chemotherapy. Antimicrob Agents Chemother 41, 363-373. Lucey, B., Cryan, B., O''Halloran, F., Wall, P.G., Buckley, T., Fanning, S., 2002, Trends in antimicrobial susceptibility among isolates of Campylobacter species in Ireland and the emergence of resistance to ciprofloxacin. Vet Rec 151, 317-320. Mann, J.E., Smith, L., Brashears, M.M., 2004, Validation of time and temperature values as critical limits for Salmonella and background flora growth during the production of fresh ground and boneless pork products. J Food Prot 67, 1389-1393. Marimon, J.M., Gomariz, M., Zigorraga, C., Cilla, G., Perez-Trallero, E., 2004, Increasing prevalence of quinolone resistance in human nontyphoid Salmonella enterica isolates obtained in Spain from 1981 to 2003. Antimicrob Agents Chemother 48, 3789-3793. McCall, C.E., Martin, W.T., Boring, J.R., 1966, Efficiency of cultures of rectal swabs and faecal specimens in detecting Salmonella carriers: correlation with numbers of Salmonellas excreted. J Hyg (Lond) 64, 261-269. McDermott, P.F., Bodeis, S.M., English, L.L., White, D.G., Walker, R.D., Zhao, S., Simjee, S., Wagner, D.D., 2002, Ciprofloxacin resistance in Campylobacter jejuni evolves rapidly in chickens treated with fluoroquinolones. J Infect Dis 185, 837-840. McEwen, S.A., Fedorka-Cray, P.J., 2002, Antimicrobial use and resistance in animals. Clin Infect Dis 34 Suppl 3, S93-S106. Mead, P.S., Slutsker, L., Griffin, P.M., Tauxe, R.V., 1999, Food-related illness and death in the united states reply to dr. hedberg. Emerg Infect Dis 5, 841-842. Miller, G.Y., Algozin, K.A., McNamaa, P.E., Bush, E.J., USDA, A., 2003, Productivity and economic effects of antibiotics used for growth promotion in U.S. pork production. Journal of agricultural and applied economics 35, 469-482. Miller, G.Y., Liu, X., McNamara, P.E., Barber, D.A., 2005, Influence of Salmonella in pigs preharvest and during pork processing on human health costs and risks from pork. J Food Prot 68, 1788-1798. Murase, T., Yamada, M., Muto, T., Matsushima, A., Yamai, S., 2000, Fecal excretion of Salmonella enterica serovar typhimurium following a food-borne outbreak. J Clin Microbiol 38, 3495-3497. Nachamkin, I., Ung, H., Li, M., 2002, Increasing fluoroquinolone resistance in Campylobacter jejuni, Pennsylvania, USA,1982-2001. Emerg Infect Dis 8, 1501-1503. Nollet, N., Maes, D., Duchateau, L., Hautekiet, V., Houf, K., Van Hoof, J., De Zuttera, L., De Kruif, A., Geers, R., 2005, Discrepancies between the isolation of Salmonella from mesenteric lymph nodes and the results of serological screening in slaughter pigs. Vet Res 36, 545-555. Ochman, H., Lawrence, J.G., Groisman, E.A., 2000, Lateral gene transfer and the nature of bacterial innovation. Nature 405, 299-304. Pearson, C.A., 1995, The role of district hospitals and the action in international medicine network. Infect Dis Clin North Am 9, 391-405. Poppe, C., McFadden, K.A., Demczuk, W.H., 1996, Drug resistance, plasmids, biotypes and susceptibility to bacteriophages of Salmonella isolated from poultry in Canada. Int J Food Microbiol 30, 325-344. Reed, W.M., Olander, H.J., Thacker, H.L., 1986, Studies on the pathogenesis of Salmonella typhimurium and Salmonella choleraesuis var kunzendorf infection in weanling pigs. Am J Vet Res 47, 75-83. Sakai, T., Chalermchaikit, T., 1996, The major sources of Salmonella enteritidis in Thailand. Int J Food Microbiol 31, 173-180. Singer, R.S., Finch, R., Wegener, H.C., Bywater, R., Walters, J., Lipsitch, M., 2003, Antibiotic resistance--the interplay between antibiotic use in animals and human beings. Lancet Infect Dis 3, 47-51. Smith, D.L., Harris, A.D., Johnson, J.A., Silbergeld, E.K., Morris, J.G., Jr., 2002, Animal antibiotic use has an early but important impact on the emergence of antibiotic resistance in human commensal bacteria. Proc Natl Acad Sci U S A 99, 6434-6439. Smith, H., 1967, The effect of the use of antibacterial drugs, particularly as food additives, on the emergence of drug-resistant strains of bacteria in animals. N Z Vet J 15, 153-166. Smith, H.W., Jones, J.E., 1967, Observations on experimental oral infection with Salmonella dublin in calves and Salmonella choleraesuis in pigs. J Pathol Bacteriol 93, 141-156. Steinbach, G., Hartung, M., 1999, [Attempt to estimate the share of human Salmonella infections, which are attributable to Salmonella originating from swine]. Berl Munch Tierarztl Wochenschr 112, 296-300. Stilianakis, N.I., Perelson, A.S., Hayden, F.G., 1998, Emergence of drug resistance during an influenza epidemic: insights from a mathematical model. J Infect Dis 177, 863-873. Stoycheva, M.V., Murdjeva, M.A., 2006, Antimicrobial therapy of salmonelloses--current state and perspectives. Folia Med (Plovdiv) 48, 5-10. Struelens, M.J., 1998, The epidemiology of antimicrobial resistance in hospital acquired infections: problems and possible solutions. BMJ 317, 652-654. Su, L.H., Chiu, C.H., Kuo, A.J., Chia, J.H., Sun, C.F., Leu, H.S., Wu, T.L., 2001, Secular trends in incidence and antimicrobial resistance among clinical isolates of Salmonella at a university hospital in Taiwan, 1983-1999. Epidemiol Infect 127, 207-213. Swartz, M.N., 2002, Human diseases caused by foodborne pathogens of animal origin. Clin Infect Dis 34 Suppl 3, S111-122. Threlfall, E.J., 2002, Antimicrobial drug resistance in Salmonella: problems and perspectives in food- and water-borne infections. FEMS Microbiol Rev 26, 141-148. Threlfall, E.J., Ward, L.R., Skinner, J.A., Rowe, B., 1997, Increase in multiple antibiotic resistance in nontyphoidal Salmonellas from humans in England and Wales: a comparison of data for 1994 and 1996. Microb Drug Resist 3, 263-266. Wang, Y.C., Yeh, K.S., Chang, C.C., Hsuan, S.L., Chen, T.H., 2006, Fluoroquinolone-resistant Salmonella sp. in carcasses. Emerg Infect Dis 12, 351-352. Wegener, H.C., 1998, Historical yearly usage of glycopeptides for animals and humans: the American-European paradox revisited. Antimicrob Agents Chemother 42, 3049. Wegener, H.C., Aarestrup, F.M., Jensen, L.B., Hammerum, A.M., Bager, F., 1999, Use of antimicrobial growth promoters in food animals and Enterococcus faecium resistance to therapeutic antimicrobial drugs in Europe. Emerg Infect Dis 5, 329-335. Wetzstein, H.G., Schmeer, N., Karl, W., 1997, Degradation of the fluoroquinolone enrofloxacin by the brown rot fungus Gloeophyllum striatum: identification of metabolites. Appl Environ Microbiol 63, 4272-4281. WHO, 2006, Five keys to safer food manual. Geneva: World Health Organization. Wilcox, M.H., Spencer, R.C., 1992, Quinolones and Salmonella gastroenteritis. J Antimicrob Chemother 30, 221-228. Wise, R., 1998, Antimicrobial resistance is a major threat to public health (Editorial). BMJ 317, 609-610. Witte, W., 2000, Selective pressure by antibiotic use in livestock. Int J Antimicrob Agents 16, S19-24. Wiuff, C., Lykkesfeldt, J., Svendsen, O., Aarestrup, F.M., 2003, The effects of oral and intramuscular administration and dose escalation of enrofloxacin on the selection of quinolone resistance among Salmonella and coliforms in pigs. Res Vet Sci 75, 185-193. Wood, R.L., Pospischil, A., Rose, R., 1989, Distribution of persistent Salmonella Typhimurium infection in internal organs of swine. Am J Vet Res 50, 1015-1021.
摘要: 
抗生素的使用可促使人類及動物中抗藥性細菌的出現。通過進食或處理受抗藥性細菌污染的肉類,人類中某部分的抗藥性細菌可能是來自動物。然而,目前這方面的研究主要是利用橫斷式的研究法,因此沒辦法完全去評估動物所造成的影響。這個研究的目的是建立一個數學模組並以抗氟奎林之豬霍亂沙門氏菌為研究對象探討此菌在豬隻及人類間的傳播。在動物及人類中抗氟奎林之豬霍亂沙門氏菌之盛行率的瞬時變化主要考慮了動物及人當中氟奎林藥物之施用頻率、沙門氏菌排放於環境的汙染及人與豬間的傳播率等因子以微分方程式表示。研究結果顯示人類中抗氟奎林之豬霍亂沙門氏菌的盛行率主要受到人類中抗生素的處方率之影響而大幅改變。換句話說,增加人類中氟奎林的使用率會加速以及擴大抗氟奎林之豬霍亂沙門氏菌在人類中出現的情形。然而,豬隻中氟奎林的使用只會加快抗氟奎林之豬霍亂沙門氏菌的出現,人類中抗氟奎林之豬霍亂沙門氏菌的盛行率的最終平衡盛行率並不會因此而顯著改變。此外,增加人類暴露抗藥性細菌的機會若增加,如不正確處理肉品而增加進食受污染的肉類,會增加抗氟奎林之豬霍亂沙門氏菌在人類中出現的風險。為了緩減抗氟奎林之豬霍亂沙門氏菌的感染情形,這個研究提出單憑減少動物中抗生素的使用是不會減少人類中抗氟奎林之豬霍亂沙門氏菌的最終盛行率;更多的努力需針對有效避免人類中抗生素不必要的使用。

The use of antibiotics is known to promote development of antibiotic-resistant (AR) bacteria either in animals or humans. Through consumption or handling of contaminated meat, certain AR bacteria in humans have been suspected to be from animal sources. However, as current studies relevant to this issue are mainly based on cross-sectional investigations, such an impact cannot be reasonably evaluated. In this study, a mathematical model consisting of a dynamic animal-and-human model was constructed to explore the transmission dynamics of FQR Salmonella Choleraesuis in pigs and humans. Prevalence of FQR S. Choleraesuis in animals and humans over time were simulated by a set of coupled differential equations. Our results indicate that the prevalence of FQR S. Choleraesuis in humans is strongly affected by antibiotic prescription in humans. That is, more fluorquinolones used in humans can hasten and amplify the occurrence of FQR S. Choleraesuis in humans. However, using fluoroquinolones in pigs can only speed up the appearance of FQR S. Choleraesuis in humans, but may not affect their long-term prevalence. Furthermore, more exposure sources of FQR S. Choleraesuis in humans, such as improper cooking or handling of contaminated meat, will increase the risk for the onset of FQR S. Choleraesuis and their equilibrium prevalence. To combat FQR S. Choleraesuis infection, our model suggests that a decrease in antibiotic use in animal husbandry alone will have little effect on equilibrium prevalence of resistant bacteria among humans. Substantial efforts must be made to avoid unnecessary use of antibiotics in humans.
URI: http://hdl.handle.net/11455/66368
其他識別: U0005-3006201111545400
Appears in Collections:微生物暨公共衛生學研究所

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