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標題: 可注射性骨泥構成之藥物制放系統(I)
The Drug-Delivery System Using Injectable Bone Cements (I)
作者: 陳震漢
關鍵字: 應用研究;calcium phosphate cement;醫學工程;鈣磷骨水泥;高分子;骨修補;藥物制放;polymer;bone repair;drug release

To date, a variety of materials have been clinically evaluated as replacements for damaged hard tissues to fill bone defects. In order to be suitable for bone tissue repair, a synthetic material must be biocompatible and it should exhibit some structural and mechanical equivalence to bone. Bone is a composite material and consists mainly of an organic matrix (collagen) and a mineral phase (hydroxyapatite). Thus, the successful design of bone substitute materials should be an analogue of the bone structure. With the increasing popularity of minimally invasive techniques, to develop injectable systems that mould to the shape of a bone cavity and polymerize when injected in situ has attracted a great deal of attention. Among many biomaterials, calcium phosphate cement can conform these requirements. It is a good bioactive material for bone defect repair in orthopedic and dental surgery due to its mechanical properties, osteoconductivity, biocompatibility, and non-toxin degradation.Antibiotic loaded materials are also used to treat the infected bone tissue and/or prevent bone tissue from the infection after surgery in dentistry and orthopedics. Incorporation of antibiotics in bone cements and their controlled release over time is thought to yield higher antibiotic concentrations to the (infected) bone or tissue site than can be achieved by systemic routes. Our principal objective of this two-year proposal is to develop the novel elastomeric calcium phosphate cement associated with controllable drug release. The cements as drug carriers to treat the infected bones or to sterilize the lesions may function additionally as potential bone substitutes, or may accelerate the bone-healing process. In addition to advanced academic study through a series of system design, it would be performed the feasibility of the clinical practice.The first-year program is to examine the effect of natural polymer such as gelatin, chitosan, and alginate on setting time, diametral tensile strength, and biodegradation of calcium phosphate cements. Processing methods involves the fabrication parameter optimum of an organic-inorganic hybrid composite consisting of naturally polymeric gelatin and bioactive calcium phosphate cements. Properties of the series of organic-inorganic composites will be characterized using a variety of techniques, including thorough microstructural and chemical analyses, testing of mechanical properties, and measurement of biodegradation in the simulated body fluid. In the second year, this study will focus the drug release profile of the antibiotics from the cement containing antibiotics. Characterization of cement samples before and after drug release will be performed. Combination of basic science and medical practice, results of this two-year research are expected to have a significant potency in the areas of biomaterials science and biotechnology.
其他識別: NSC97-2221-E005-078
Appears in Collections:微生物暨公共衛生學研究所

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