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標題: 大腸桿菌系統表現之雞傳染性華氏囊病類病毒顆粒攜帶傳染性支氣管炎S1蛋白二價次單位疫苗之研發與應用
Divalent Vaccine of Infectious Bursal Disease Virus-Like Particle Carrying Infectious Bronchitis S1 Protein Expressed by E. Coli
作者: 謝明昆
關鍵字: 應用研究;Avian Infectious Bronchitis;畜牧獸醫類, 生物技術;雞傳染性支氣管炎;雞傳染性華氏囊病;次單位疫苗;Infectious Bursal Disease;Subunit Vaccine

Avian infectious bronchitis (IB) and infectious bursal disease (IBD) are highly contagious and usually cause economic loses in poultry industry in Taiwan. Due to the high affinity between IBD VP243 protein particle and immune cells such as bursal B cells and marcrophages, the fusion protein of S1-VP243 prepared by cloning IB S1 protein on the N terminal of IBDV VP243 protein and expressed by E. coli system will be able to stimulate various immune cells and increase humoral and cellular immune responses against both of IB and IBD infections. Moreover, a rapid response system against emerging infectious will be established by vaccinating health chickens with vaccines prepared by cloning antigens obtained from the emerging pathogen on on the N terminal of IBDV VP243 protein.
其他識別: 98農科-1.1.5-檢-B1(5)
Appears in Collections:微生物暨公共衛生學研究所

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