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|標題:||Identification of Escherichia coli Genes Associated with Urinary Tract Infections||作者:||Mao, B.H.
|關鍵字:||shi-2 pathogenicity island;complete genome sequence;shigella-flexneri;strains;virulence;pathogenesis;uropathogen;pathotypes;phylogeny;traits||Project:||Journal of Clinical Microbiology||期刊/報告no：:||Journal of Clinical Microbiology, Volume 50, Issue 2, Page(s) 449-456.||摘要:||
Escherichia coli is the most common cause of urinary tract infections (UTIs). E. coli genes epidemiologically associated with UTIs are potentially valuable in developing strategies for treating and/or preventing such infections as well as differentiating uropathogenic E. coli from nonuropathogenic E. coli. To identify E. coli genes associated with UTIs in humans, we combined microarray-based and PCR-based analyses to investigate different E. coli source groups derived from feces of healthy humans and from patients with cystitis, pyelonephritis, or urosepsis. The cjrABC-senB gene cluster, sivH, sisA, sisB, eco274, and fbpB, were identified to be associated with UTIs. Of these, cjrABC-senB, sisA, sisB, and fbpB are known to be involved in urovirulence in the mouse model of ascending UTI. Our results provide evidence to support their roles as urovirulence factors in human UTIs. In addition, the newly identified UTI-associated genes were mainly found in members of phylogenetic groups B2 and/or D.
|Appears in Collections:||微生物暨公共衛生學研究所|
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