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標題: The identification of frequent variations in the fusion protein of canine distemper virus
作者: Lee, M.S.
Tsai, K.J.
Chen, L.H.
Chen, C.Y.
Liu, Y.P.
Chang, C.C.
Lee, S.H.
Hsu, W.L.
關鍵字: Fusion protein;Canine distemper virus;Genetic diversity;Pre-peptide;region;hemagglutinin;dogs;japan;infection;sequence;genes;entry;mice
Project: Veterinary Journal
期刊/報告no:: Veterinary Journal, Volume 183, Issue 2, Page(s) 184-190.
Canine distemper (CD) is a highly contagious disease with a worldwide distribution. Genetic diversity in genes encoding the haemagglutinin (H) and fusion (F) virus envelope proteins have been implicated in the increasing incidence of CD. Unlike the H gene, little is known about the genetic variability of the F gene in this virus. In the present study sequence analysis of the complete coding region of the F protein from CD virus isolates from Taiwan were carried out. Phylogenetic analysis demonstrated that the majority of isolates were similar to those found in neighbouring China and Japan, but were genetically distinct from vaccine strains. Remarkable variations were found scattered throughout the pre-peptide region (residues 1-135). The sequence identity of this region between locally sourced strains and between these strains and vaccine strains was 89% and 64 to 67%, respectively. Analysis suggested a novel strain of distant genetic lineage was present in dogs in the geographically isolated city of Hualien. (C) 2008 Elsevier Ltd. All rights reserved.
ISSN: 1090-0233
DOI: 10.1016/j.tvjl.2008.10.001
Appears in Collections:微生物暨公共衛生學研究所

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