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標題: Immunogenicity and efficacy of three recombinant subunit Pasteurella multocida toxin vaccines against progressive atrophic rhinitis in pigs
作者: Liao, C.M.
Huang, C.J.
Hsuan, S.L.
Chen, Z.W.
Lee, W.C.
Liu, C.I.
Winton, J.R.
Chien, M.S.
關鍵字: ELISPOT;Pasteurella multocida toxin;recombinant subunit vaccine;bordetella-bronchiseptica;experimental-infection;escherichia-coli;b-bronchiseptica;bone-resorption;protein toxin;serotype-d;vaccination;osteoblasts;osteoclasts
Project: Vaccine
期刊/報告no:: Vaccine, Volume 24, Issue 1, Page(s) 27-35.
Three short fragments of recombinant subunit Pasteurella multocida toxin (rsPMT) were constructed for evaluation as candidate vaccines against progressive atrophic rhinitis (PAR) of swine. PMT-specific antibody secreting cells and evidence of cellular immunity were detected in rsPMT-immunized pigs following authentic PMT challenge or homologous antigen booster. Piglets immunized with rsPMT fragments containing either the N-terminal or the C-terminal portions of PMT developed high titers of neutralizing antibodies. Pregnant sows immunized with rsPMT had higher levels of maternal antibodies in their colostrum than did those immunized with a conventional PAR-toxoid vaccine. Offspring from rsPMT vaccinated sows had better survival after challenge with a five-fold lethal dose of authentic PMT and had better growth performance after challenge with a sublethal dose of toxin. Our findings indicate these non-toxic rsPMT proteins are attractive candidates for development of a subunit vaccine against PAR in pigs. (c) 2005 Elsevier Ltd. All rights reserved.
ISSN: 0264-410X
DOI: 10.1016/j.vaccine.2005.07.079
Appears in Collections:微生物暨公共衛生學研究所

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