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標題: Efficacy of a novel Pasteurella multocida vaccine against progressive atrophic rhinitis of swine
作者: Hsuan, S.L.
Liao, C.M.
Huang, C.J.
Winton, J.R.
Chen, Z.W.
Lee, W.C.
Liao, J.W.
Chen, T.H.
Chiou, C.J.
Yeh, K.S.
Chien, M.S.
關鍵字: Progressive atrophic rhinitis;Pasteurella multocida toxin;Recombinant;subunit vaccine;bordetella-bronchiseptica;dermonecrotic toxin;turbinate atrophy;b-bronchiseptica;p-multocida;serotype-d;pigs;protection;immunogenicity;induction
Project: Vaccine
期刊/報告no:: Vaccine, Volume 27, Issue 22, Page(s) 2923-2929.
The efficacy of a novel vaccine composed of three short recombinant subunit Pasteurella multocida toxin (PMT) proteins in combination with a bi-vaient R multocida whole-cell bacterin (rsPMT-PM) was evaluated in field studies for prevention and control of progressive atrophic rhinitis (PAR) of swine at 15 conventional farrow-to-finish farms. Experimental piglets that were immunized twice with the rsPMT-PM vaccine developed detectable titers of neutralizing antibodies (greater than 1:8) that prevented the growth retardation and pathological lesions typically observed following challenge with authentic PMT. A total of 542 sows were vaccinated once or twice prior to parturition and serum neutralizing antibody titers were evaluated. Both single and double vaccination protocols induced neutralizing antibody titers of 1: 16 or higher in 62% and 74% of sows, respectively. Notably, neither sows nor piglets at a farm experiencing a severe outbreak of PAR at the time of the vaccination trial had detectable antibody titers, but antibody titers increased significantly to 1:16 or higher in 40% of sows following double vaccination. During the year after vaccination, clinical signs of PAR decreased in fattening pigs and growth performance improved sufficiently to reduce the rearing period until marketing by 2 weeks. Collectively, these results indicate that the rsPMT-PM vaccine could be used to provide protective immunity for controlling the prevalence and severity of PAR among farm-raised swine. (C) 2009 Elsevier Ltd. All rights reserved.
ISSN: 0264-410X
DOI: 10.1016/j.vaccine.2009.03.005
Appears in Collections:微生物暨公共衛生學研究所

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