Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/66679
DC FieldValueLanguage
dc.contributor.authorLin, H.W.en_US
dc.contributor.author張天傑zh_TW
dc.contributor.authorHsu, W.L.en_US
dc.contributor.authorChang, Y.Y.en_US
dc.contributor.authorJan, M.S.en_US
dc.contributor.authorWong, M.L.en_US
dc.contributor.authorChang, T.J.en_US
dc.contributor.author徐維莉zh_TW
dc.contributor.author王孟亮zh_TW
dc.date2010zh_TW
dc.date.accessioned2014-06-11T05:46:58Z-
dc.date.available2014-06-11T05:46:58Z-
dc.identifier.issn0916-7250zh_TW
dc.identifier.urihttp://hdl.handle.net/11455/66679-
dc.description.abstractThe vhs (virion host shutoff) is highly conserved in alphaherpesvirus, including pseudorabies virus (PRV). In an attempt to explore the function of vhs of PRV, we constructed and characterized a mutant virus (Delta 41). In the absence of vhs activity, Delta 41 mutant is highly attenuated in mice model and the lethality is correlated with the virus dissemination in neural tissues. As with herpes simplex virus type 1 (HSV-1), the prototype virus or alphaherpesvirus, the pronounced decrease in cellular protein synthesis triggered by wild type PRV was largely restored in cells infected with Delta 41 virus. Furthermore, tumor necrosis factor-alpha (TNF-alpha) protein expression was elevated significantly in spleen of mice infected with vhs mutant virus. Since TNF-alpha has been indicated to be an important cytokine in the innate immune response against various infections, our results implicate vhs may contribute to the protection against PRV lethality via the action of TNF-alpha. Overall, we confirm the shutoff function of vhs protein in PRV, and demonstrate the role that vhs protein plays in virulence, and regulation of cytokine production.en_US
dc.language.isoen_USzh_TW
dc.relationJournal of Veterinary Medical Scienceen_US
dc.relation.ispartofseriesJournal of Veterinary Medical Science, Volume 72, Issue 9, Page(s) 1179-1187.en_US
dc.subjectpseudorabies virus (PRV)en_US
dc.subjecttumor necrosis factor-alpha (TNF-alpha)en_US
dc.subjectUL41en_US
dc.subjectvirion host shutoff (vhs) proteinen_US
dc.subjectherpes-simplex-virusen_US
dc.subjectcellular messenger-rnasen_US
dc.subjectbovine herpesvirus-1en_US
dc.subjectinfectionen_US
dc.subjecttype-1en_US
dc.subjectcellsen_US
dc.subjectgeneen_US
dc.subjectvhsen_US
dc.subjectherpes-simplex-virus-1en_US
dc.subjectmechanismsen_US
dc.titleRole of the UL41 Protein of Pseudorabies Virus in Host Shutoff, Pathogenesis and Induction of TNF-alpha Expressionen_US
dc.typeJournal Articlezh_TW
item.languageiso639-1en_US-
item.openairetypeJournal Article-
item.cerifentitytypePublications-
item.grantfulltextnone-
item.fulltextno fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
Appears in Collections:微生物暨公共衛生學研究所
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