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|標題:||Inhibition of mite-induced immunoglobulin E synthesis, airway inflammation, and hyperreactivity by herbal medicine STA-1||作者:||Chang, T.T.
|關鍵字:||airway hyperreactivity;allergy;immunoglobulin E;traditional Chinese;medicine;allergic-asthma;anti-ige;dermatophagoides-pteronyssinus;alternative;medicine;efficacy;tang;hyperresponsiveness;infiltration;responses;children||Project:||Immunopharmacology and Immunotoxicology||期刊/報告no：:||Immunopharmacology and Immunotoxicology, Volume 28, Issue 4, Page(s) 683-695.||摘要:||
The availability of STA-1 in suppressing allergen-induced immunoglobulin E (IgE) synthesis, airway inflammation and hyperreactivity in a murine model was investigated. The mice were intraperitoneally sensitized with Dermatophagoides pteronyssinus group 5 allergen (Der p 5) and orally treated with 300 mg/kg of STA-1 every other day for 14 days. The Der p 5-specific immunologic responses including changes of specific immunoglobulin G and E, cells in the broncholarvage fluid, and airway hyperreactivity were measured when mice received inhalation challenge with Der p 5 after sensitization for 21 days. By comparing with sham-treated groups, the synthesis of Der p 5-specific IgE was downregulated while the influx of eosinophils and neutrophils in the airway were remarkably reduced. In addition, Der p 5-induced airway hyperreactivity also was significantly eliminated by STA-1 treatment. These results showed that STA-1 could effectively suppress the Der p 5-induced allergic reactions, and the availability of STA-1 for the treatment of allergic asthma was demonstrated in this study.
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