Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/67770
DC FieldValueLanguage
dc.contributor.authorYang, C.C.en_US
dc.contributor.authorYang, S.Y.en_US
dc.contributor.authorChieh, J.J.en_US
dc.contributor.authorHorng, H.E.en_US
dc.contributor.authorHong, C.Y.en_US
dc.contributor.authorYang, H.C.en_US
dc.contributor.authorChen, K.H.en_US
dc.contributor.authorShih, B.Y.en_US
dc.contributor.authorChen, T.F.en_US
dc.contributor.authorChiu, M.J.en_US
dc.date2011zh_TW
dc.date.accessioned2014-06-11T05:55:39Z-
dc.date.available2014-06-11T05:55:39Z-
dc.identifier.issn1948-7193zh_TW
dc.identifier.urihttp://hdl.handle.net/11455/67770-
dc.description.abstractMagnetic nanoparticles biofunctionalized with antibodies against beta-amyloid-40 (A beta-40) and A beta-42, which are promising biomarkers related to Alzheimer's disease (AD), were synthesized. We characterized the size distribution, saturated magnetizations, and stability of the magnetic nanoparticles conjugated with anti-A beta antibody. In combination with immunomagnetic reduction technology, it is demonstrated such biofunctionalized magnetic nanoparticles are able to label A beta s specifically. The ultralow-detection limits of assaying A beta s in vitro using the magnetic nanoparticles via immunomagnetic reduction are determined to a concentration of similar to 10 ppt (10 pg/mL). Further, immunomagnetic reduction signals of A beta-40 and A beta-42 in human plasma from normal samples and AD patients were analyzed, and the results showed a significant difference between these two groups. These results show the feasibility of using magnetic nanoparticles with A beta s as reagents for assaying low-concentration A beta s through immunomagnetic reduction, and also provide a promising new method for early diagnosis of Alzheimer's disease from human blood plasma.en_US
dc.language.isoen_USzh_TW
dc.relationAcs Chemical Neuroscienceen_US
dc.relation.ispartofseriesAcs Chemical Neuroscience, Volume 2, Issue 9, Page(s) 500-505.en_US
dc.relation.urihttp://dx.doi.org/10.1021/cn200028jen_US
dc.subjectMagnetic nanoparticlesen_US
dc.subjectbeta-amyloiden_US
dc.subjectimmunomagnetic reductionen_US
dc.subjectplasma-a-betaen_US
dc.subjectcerebrospinal-fluiden_US
dc.subjectimmunoassayen_US
dc.titleBiofunctionalized Magnetic Nanoparticles for Specifically Detecting Biomarkers of Alzheimer's Disease in Vitroen_US
dc.typeJournal Articlezh_TW
dc.identifier.doi10.1021/cn200028jzh_TW
item.languageiso639-1en_US-
item.grantfulltextnone-
item.cerifentitytypePublications-
item.fulltextno fulltext-
item.openairetypeJournal Article-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
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