Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/68087
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dc.contributor.authorChou, Y.Y.en_US
dc.contributor.authorSheu, W.H.H.en_US
dc.contributor.authorTang, Y.J.en_US
dc.contributor.authorChen, Y.M.en_US
dc.contributor.authorLiao, S.C.en_US
dc.contributor.authorChuang, Y.W.en_US
dc.contributor.authorLin, C.S.en_US
dc.contributor.authorChen, D.Y.en_US
dc.date2009zh_TW
dc.date.accessioned2014-06-11T05:56:15Z-
dc.date.available2014-06-11T05:56:15Z-
dc.identifier.issn0167-4943zh_TW
dc.identifier.urihttp://hdl.handle.net/11455/68087-
dc.description.abstractCirculating levels of inflammatory and prothrombotic factors are elevated in the metabolic syndrome (MS) and linked with the occurrence of cardiovascular events. The aim of our study was to investigate the relationship between inflammatory and prothrombotic markers and the MS in elderly institutionalized residents. A total of 326 non-diabetic residents of Chuang-Hua Veterans Care Home (age: 79.9 +/- 4.1 years; 100% males) were enrolled. MS was diagnosed according to the AHA/NHLBI Scientific Statement criteria. Body fat percentage was measured by bioelectrical impedance analysis. Insulin resistance was calculated by homeostasis model assessment for insulin resistance (HOMA-IR). Inflammatory markers, including tumor necrosis factor-alpha (TNF-alpha), high sensitivity C-reactive protein (hsCRP), and plasminogen activator inhibitor-1 (PAI-1), were determined using ELISA. Elderly residents with the MS had higher systolic and diastolic blood pressures (both p < 0.001) and higher HOMA-IR (p < 0.001), hsCRP (p = 0.008), and PAI-1 levels (p < 0.001) than those without the MS. On multivariate logistic regression analysis, PAI-1 was an independent risk factor for the MS. Of the MS components, elderly residents with higher waist circumferences and higher levels of plasma fasting glucose, and triglyceride (TG), and lower levels of high density lipoprotein (HDL) had higher PAI-1 levels than those without the above components. (c) 2009 Elsevier Ireland Ltd. All rights reserved.en_US
dc.language.isoen_USzh_TW
dc.relationArchives of Gerontology and Geriatricsen_US
dc.relation.ispartofseriesArchives of Gerontology and Geriatrics, Volume 49, Page(s) S41-S45.en_US
dc.subjectPlasminogen activator inhibitor type-1 (PAI-1)en_US
dc.subjectMetabolic syndrome (MS)en_US
dc.subjectInstitutionalized elderly residentsen_US
dc.subjectc-reactive proteinen_US
dc.subjectinsulin-resistance syndromeen_US
dc.subjecttnf-alphaen_US
dc.subjectmyocardial-infarctionen_US
dc.subjectplasma-insulinen_US
dc.subjectinflammationen_US
dc.subjectglucoseen_US
dc.subjectobesityen_US
dc.subjectadultsen_US
dc.subjectrisken_US
dc.titlePlasminogen activator inhibitor type 1 (PAI-1) is a valuable biomarker for predicting the metabolic syndrome (MS) in institutionalized elderly residents in Taiwanen_US
dc.typeJournal Articlezh_TW
item.openairetypeJournal Article-
item.fulltextno fulltext-
item.grantfulltextnone-
item.languageiso639-1en_US-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
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