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|標題:||Effects of dietary arsenical inclusion on lipid metabolism and liver function in mule ducks||作者:||Chen, K.L.
|關鍵字:||arsenical;fatty liver;lipid metabolism;mule duck;roxarsone;roxarsone;performance||Project:||Asian-Australasian Journal of Animal Sciences||期刊/報告no：:||Asian-Australasian Journal of Animal Sciences, Volume 19, Issue 3, Page(s) 412-417.||摘要:||
This study evaluated the effectiveness of different arsenical Sources oil inducing fatty liver, on changes, in lipid metabolism and on liver function in mule ducks. Sixty twelve-week-old mule ducks were selected and randomly divided into five treatments. including the control group and four different arsenical sources: Roxarsone (300 mg/kg), arsanlilte acid or As2O5 or As2O3 containing 85.2 mg/kg arsenic were included in the basal diet. The ducks were fed the medicated basal diet for 3 weeks followed by a one-week drug withdrawal. The results showed Roxarsone treatment decreased bode weight, feed intake. liver weight and abdominal fat weight (p < 0.05). while it increased the relative liver weight (p < 0.05) during Medication period (3(rd) week). The As2O5 treatment decreased abdominal fat weight and relative abdominal fat weight and relative abdominal fat weight when compared to the control (p < 0.05). Only Roxarsone among the treatment group increased feed intake, liver weight and relative liver weight, while the As2O3 group showed the lightest liver weight and relative liver weight among treatment groups during the withdrawal period (4(th) week). The Roxarsone group decreased (p < 0.05) NADP-malic dehydrogenase (MDH) and acetyl-CoA carboxylase (ACC) activities and increased (p < 0.05) cholesterol concentration during the medication period, and elevated the MDH and ACC activities during the withdrawal period. All four arsenical treatment groups showed lymphocytic infiltration in liver tissue, while the Roxarsone and As2O3 treatments showed an increase in aspartate aminotransferase (AST) and lactate dehydrogenase (LDH) activities (p < 0.05). During the withdrawal period arsenical treatments resulted in liver vacuoles. However, the arsenical differed in effectiveness and mechanism of inducing fat vacuoles.
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