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|標題:||Genetic variation of viral protein 1 genes of field strains of waterfowl parvoviruses and their attenuated derivatives||作者:||Tsai, H.J.
|關鍵字:||waterfowl parvovirus;goose parvovirus;Muscovy duck parvovirus;viral;protein I (VPI);nucleotide sequences;muscovy duck parvovirus;disease;virus;ducklings;goslings;taiwan;system;goose||Project:||Avian Diseases||期刊/報告no：:||Avian Diseases, Volume 48, Issue 3, Page(s) 512-521.||摘要:||
To understand the genetic variations between the field strains of waterfowl parvoviruses and their attenuated derivatives, we analyzed the complete nucleotide sequences of the viral protein 1 (VP1) genes of nine field strains and two vaccine strains of waterfowl parvoviruses. Sequence comparison of the VP1 proteins showed that these viruses could be divided into goose parvovirus (GPV) related and Muscovy duck parvovirus (MDPV) related groups. The amino acid difference between GPV- and MDPV-related groups ranged from 13.1% to 15.8%, and the most variable region resided in the N terminus of VP2. The vaccine strains of GPV and MDPV exhibited only 1.2% and 0.3% difference in amino acid when compared with their parental field strains, and most of these differences resided in residues 497-575 of VP1, suggesting that these residues might be important for the attenuation of GPV and MDPV. When the GPV strains isolated in 1982 (the strain 82-0308) and in 2001 (the strain 01-1001) were compared, only 0.3% difference in amino acid was found, while MDPV strains isolated in 1990 (the strain 90-0219) and 1997 (the strain 97-0104) showed only 0.4% difference in amino acid. The result indicates that the genome of waterfowl parvovirus had remained highly stable in the field.
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