Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/68161
DC FieldValueLanguage
dc.contributor.authorRaung, S.L.en_US
dc.contributor.authorChen, S.Y.en_US
dc.contributor.authorLiao, S.L.en_US
dc.contributor.authorChen, J.H.en_US
dc.contributor.authorChen, C.J.en_US
dc.date2005zh_TW
dc.date.accessioned2014-06-11T05:56:20Z-
dc.date.available2014-06-11T05:56:20Z-
dc.identifier.issn0006-291Xzh_TW
dc.identifier.urihttp://hdl.handle.net/11455/68161-
dc.description.abstractThe cellular signaling molecules that underlie Japanese encephalitis virus (JEV)-induced inflammation and neurotoxicity are not well understood. We examined whether protein tyrosine kinase (PTK) inhibitors play roles in JEV replication and cytopathic effect in neuron/glia cultures. JEV infection caused significant neuronal injury. PTK inhibitors. genistein, herbimycin A, and PP2, attenuated JEV-induced neurotoxicity but failed to affect JEV replication. Infection of neuron/glia cultures with JEV produced elevated levels of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta). PTK inhibitors suppressed JEV-induced TNF-alpha and lL-1beta production at the transcriptional level. Neutralizing antibodies against TNF-alpha and IL-1beta partially supressed JEV-induced neurotoxicity. JEV infection modulated tyrosine phosphorylation events within the course of infection. Currently, the nature of the affected phosphorylated proteins was not characterized. Our results suggest that PTKs, especially Src-related PTK. play roles in the production of TNF-alpha and IL-1beta during JEV infection and in the induction of neuronal death in neuron/glia cultures. (C) 2004 Elsevier Inc. All rights reserved.en_US
dc.language.isoen_USzh_TW
dc.relationBiochemical and Biophysical Research Communicationsen_US
dc.relation.ispartofseriesBiochemical and Biophysical Research Communications, Volume 327, Issue 2, Page(s) 399-406.en_US
dc.relation.urihttp://dx.doi.org/10.1016/j.bbrc.2004.12.034en_US
dc.subjectJapanese encephalitis virusen_US
dc.subjectphosphorylationen_US
dc.subjectprotein tyrosine kinaseen_US
dc.subjectSrc kinaseen_US
dc.subjectastrocyte-enriched culturesen_US
dc.subjecttumor-necrosis-factoren_US
dc.subjectnf-kappa-ben_US
dc.subjectneuroblastoma-cellsen_US
dc.subjectgene-expressionen_US
dc.subjectup-regulationen_US
dc.subjectmixed gliaen_US
dc.subjectinfectionen_US
dc.subjectactivationen_US
dc.subjectphosphorylationen_US
dc.titleTyrosine kinase inhibitors attenuate Japanese encephalitis virus-induced neurotoxicityen_US
dc.typeJournal Articlezh_TW
dc.identifier.doi10.1016/j.bbrc.2004.12.034zh_TW
item.cerifentitytypePublications-
item.grantfulltextnone-
item.languageiso639-1en_US-
item.fulltextno fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeJournal Article-
Appears in Collections:期刊論文
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