Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/68190
DC FieldValueLanguage
dc.contributor.authorChang, C.L.T.en_US
dc.contributor.authorFung, H.P.en_US
dc.contributor.authorLin, Y.F.en_US
dc.contributor.authorKuo, C.Y.en_US
dc.contributor.authorChien, C.W.en_US
dc.date2002zh_TW
dc.date.accessioned2014-06-11T05:56:23Z-
dc.date.available2014-06-11T05:56:23Z-
dc.identifier.issn0918-6158zh_TW
dc.identifier.urihttp://hdl.handle.net/11455/68190-
dc.description.abstractIndenopyridine hydrochloride (IH), an antispermatogenic agent, was tested to determine the testicular pathological changes, seminal spermatozoa concentrations and seminal plasma alkaline phosphatase levels in male dogs. A single oral dosage of 30 mg IH/kg BW induced the dissociation and premature release of germ cells into the lumens of seminiferous tubules. Ring-shaped spermatid nuclei, nuclear pykonosis of spermatocytes and multinucleated cell associations were also observed. Thereafter, the spermatogenic index (SI) significantly decreased one day after IH administration. Moreover, seminal spermatozoa concentrations decreased two weeks after drug treatment; and there was a statistically significant difference in spermatozoa production inhibited by IH compared to the control. Reversible spermatogenesis was noted 7 weeks after IH treatment in male dogs. Meanwhile, seminal plasma alkaline phosphatase levels also significantly increased two weeks after IH treatment. These data confirm that IH might induce a two-month inhibition of spermatogenesis in male dogs.en_US
dc.language.isoen_USzh_TW
dc.relationBiological & Pharmaceutical Bulletinen_US
dc.relation.ispartofseriesBiological & Pharmaceutical Bulletin, Volume 25, Issue 8, Page(s) 1097-1100.en_US
dc.relation.urihttp://dx.doi.org/10.1248/bpb.25.1097en_US
dc.subjectindenopyridine hydrochlorideen_US
dc.subjectspermatogenesisen_US
dc.subjectalkaline phosphataseen_US
dc.subjectmale dogen_US
dc.titleIndenopyridine hydrochloride induced testicular spermatogenesis failure with high seminal alkaline phosphatase levels in male dogen_US
dc.typeJournal Articlezh_TW
dc.identifier.doi10.1248/bpb.25.1097zh_TW
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeJournal Article-
item.cerifentitytypePublications-
item.fulltextno fulltext-
item.languageiso639-1en_US-
item.grantfulltextnone-
Appears in Collections:期刊論文
Show simple item record
 

Google ScholarTM

Check

Altmetric

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.