Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/68216
標題: Reconstruction of calvarial defect using a tricalcium phosphate-oligomeric proanthocyanidins cross-linked gelatin composite
作者: Chen, K.Y.
Shyu, P.C.
Dong, G.C.
Chen, Y.S.
Kuo, W.W.
Yao, C.H.
關鍵字: Oligomeric proanthocyanidins;Cross-linking;Gelatin;Tricalcium;phosphate;Osteoconductive;Bone repair;bone substitute;in-vitro;tissue;linking;genipin;model;hydroxyapatite;biodegradation;cytotoxicity;hydrogel
Project: Biomaterials
期刊/報告no:: Biomaterials, Volume 30, Issue 9, Page(s) 1682-1688.
摘要: 
A biodegradable GTP composite which was composed of oligomeric proanthocyanidins (OPCs) crosslinked gelatin mixed with tricalcium phosphate was developed as a bone substitute. The subcutaneous implantation in rats was examined to determine the in vivo degradation and biocompatibility of the GTP composites with various cross-linking densities. Experimental results indicated that the rate of in vivo degradation was markedly attenuated as the concentration of OPCs increased above 5.0 wt%. Furthermore, this study examined the biological response of rabbit calvarial bone to GTP composite to evaluate its potential for use as an osteoconductive bone substitute. Bone defects (10 mm in diameter) in New Zealand white rabbits were filled with the GTP composite. The de-protenized bovine cancellous bone matrix was employed as the control material. The results of radiographic analyses demonstrated obviously greater new bone ingrowth in the GTP composite than in the de-proteinized bovine bone at the same implantation time. Progressive replacement of the GTP composite by new bone proceeded by a combination of osteoconduction and biodegradation. The biodegradable GTP composite thus has great potential for improving bone repair. (C) 2008 Elsevier Ltd. All rights reserved.
URI: http://hdl.handle.net/11455/68216
ISSN: 0142-9612
DOI: 10.1016/j.biomaterials.2008.12.024
Appears in Collections:期刊論文

Show full item record
 

Google ScholarTM

Check

Altmetric

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.