Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/68264
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dc.contributor.authorKao, S.C.en_US
dc.contributor.author陳鴻震zh_TW
dc.contributor.authorChen, C.Y.en_US
dc.contributor.authorWang, S.L.en_US
dc.contributor.authorYang, J.J.en_US
dc.contributor.authorHung, W.C.en_US
dc.contributor.authorChen, Y.C.en_US
dc.contributor.authorLai, N.S.en_US
dc.contributor.authorLiu, H.T.en_US
dc.contributor.authorHuang, H.L.en_US
dc.contributor.authorChen, H.C.en_US
dc.contributor.authorLin, T.H.en_US
dc.contributor.authorHuang, H.B.en_US
dc.date2007zh_TW
dc.date.accessioned2014-06-11T05:56:32Z-
dc.date.available2014-06-11T05:56:32Z-
dc.identifier.issn0006-291Xzh_TW
dc.identifier.urihttp://hdl.handle.net/11455/68264-
dc.description.abstractWe have identified a novel protein, protein phosphatase I F-actin cytoskeleton targeting subunit (phostensin). This protein is encoded by KIAA1949 and was found to associate with protein phosphatase I (PPI) in the yeast two-hybrid assay, co-immunoprecipitation, and GST pull-down assay. Northern blot analysis revealed that phostensin mRNA was predominantly distributed in leukocytes and spleen, and phostensin protein was present in crude extracts of human peripheral leukocytes. Immunofluorescence microscopic analysis revealed that the phostensin/PPI complex was conspicuously localized with the actin cytoskeleton at the cell periphery in Madin-Darby canine kidney (MDCK) epithelial cells. Taken together, our data shows that phostensin targets PPI to F-actin cytoskeleton. The phostensin/PPI complex may play a vital role in modulation of actin rearrangements. (c) 2007 Elsevier Inc. All rights reserved.en_US
dc.language.isoen_USzh_TW
dc.relationBiochemical and Biophysical Research Communicationsen_US
dc.relation.ispartofseriesBiochemical and Biophysical Research Communications, Volume 356, Issue 3, Page(s) 594-598.en_US
dc.relation.urihttp://dx.doi.org/10.1016/j.bbrc.2007.03.026en_US
dc.subjectphostensinen_US
dc.subjectKIAAI949en_US
dc.subjectprotein phosphatase 1en_US
dc.subjectactin cytoskeletonen_US
dc.subjectprotein phosphatase 1en_US
dc.subjectaffinity-chromatographyen_US
dc.subjectpurificationen_US
dc.subjectinhibitor-1en_US
dc.subjectdarpp-32en_US
dc.titleIdentification of phostensin, a PP1F-actin cytoskeleton targeting subuniten_US
dc.typeJournal Articlezh_TW
dc.identifier.doi10.1016/j.bbrc.2007.03.026zh_TW
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.languageiso639-1en_US-
item.fulltextno fulltext-
item.grantfulltextnone-
item.openairetypeJournal Article-
Appears in Collections:生命科學院
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