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標題: Crosstalk between hepatocyte growth factor and integrin signaling pathways
作者: Chan, P.C.
Chen, S.Y.
Chen, C.H.
Chen, H.C.
關鍵字: HGF;Met;integrin;FAK;crosstalk;focal adhesion kinase;receptor tyrosine kinase;canine kidney-cells;c-met;sustained activation;regulated kinase;epithelial morphogenesis;alpha-2-beta-1 integrin;endothelial-cells;invasive-growth
Project: Journal of Biomedical Science
期刊/報告no:: Journal of Biomedical Science, Volume 13, Issue 2, Page(s) 215-223.
Most types of normal cells require integrin-mediated attachment to extracellular matrix to be able to respond to growth factor stimulation for proliferation and survival. Therefore, a consensus that integrins are close collaborators with growth factors in signal transduction has gradually emerged. Some integrins and growth factor receptors appear to be normally in relatively close proximity, which can be induced to form complexes upon cell adhesion or growth factor stimulation. Moreover, since integrins and growth factor receptors share many common elements in their signaling pathways, it is clear that there are many opportunities for integrin signals to modulate growth factor signals and vice versa. Increasing evidence indicates that integrins can crosstalk with receptor tyrosine kinases in a cell- and integrin-type-dependent manner through a variety of specific mechanisms. This review is intended specifically for summarizing recent progress uncovering how the hepatocyte growth factor receptor c-Met coordinates with integrins to transmit signals.
ISSN: 1021-7770
DOI: 10.1007/s11373-005-9061-7
Appears in Collections:生命科學院

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