Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/68344
DC FieldValueLanguage
dc.contributor.authorChen, S.Y.en_US
dc.contributor.author陳鴻震zh_TW
dc.contributor.authorChen, H.C.en_US
dc.date2006zh_TW
dc.date.accessioned2014-06-11T05:56:40Z-
dc.date.available2014-06-11T05:56:40Z-
dc.identifier.issn0270-7306zh_TW
dc.identifier.urihttp://hdl.handle.net/11455/68344-
dc.description.abstractFocal adhesion kinase (FAK) has been implicated to be a point of convergence of integrin and growth factor signaling pathways. Here we report that FAK directly interacts with the hepatocyte growth factor receptor c-Met. Phosphorylation of c-Met at Tyr-1349 and, to a lesser extent, Tyr-1356 is required for its interaction with the band 4.1 and ezrin/radixin/moesin homology domain (FERM domain) of FAK. The F2 subdomain of the FAK FERM domain alone is sufficient for Met binding, in which a patch of basic residues ((216)KAKTLRK(222)) are critical for the interaction. Met-FAK interaction leads to FAK activation and subsequent contribution to hepatocyte growth factor-induced cell motility and cell invasion. Our results provide evidence that constitutive Met-FAK interaction may be a critical determinant for tumor cells to acquire invasive potential.en_US
dc.language.isoen_USzh_TW
dc.relationMolecular and Cellular Biologyen_US
dc.relation.ispartofseriesMolecular and Cellular Biology, Volume 26, Issue 13, Page(s) 5155-5167.en_US
dc.relation.urihttp://dx.doi.org/10.1128/mcb.02186-05en_US
dc.subjectreceptor tyrosine kinaseen_US
dc.subjectc-meten_US
dc.subjectferm domainen_US
dc.subjectoncogenic rearrangementen_US
dc.subjectterminal domainen_US
dc.subjectproteinen_US
dc.subjectgab1en_US
dc.subjectphosphorylationen_US
dc.subjectactivationen_US
dc.subjectmotilityen_US
dc.titleDirect interaction of focal adhesion kinase (FAK) with Met is required for FAK to promote hepatocyte growth factor-induced cell invasionen_US
dc.typeJournal Articlezh_TW
dc.identifier.doi10.1128/mcb.02186-05zh_TW
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextno fulltext-
item.cerifentitytypePublications-
item.grantfulltextnone-
item.languageiso639-1en_US-
item.openairetypeJournal Article-
Appears in Collections:生命科學院
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