Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/68423
DC FieldValueLanguage
dc.contributor.authorTan, T.W.en_US
dc.contributor.authorYang, W.H.en_US
dc.contributor.authorLin, Y.T.en_US
dc.contributor.authorHsu, S.F.en_US
dc.contributor.authorLi, T.M.en_US
dc.contributor.authorKao, S.T.en_US
dc.contributor.authorChen, W.C.en_US
dc.contributor.authorFong, Y.C.en_US
dc.contributor.authorTang, C.H.en_US
dc.date2009zh_TW
dc.date.accessioned2014-06-11T05:56:47Z-
dc.date.available2014-06-11T05:56:47Z-
dc.identifier.issn0143-3334zh_TW
dc.identifier.urihttp://hdl.handle.net/11455/68423-
dc.description.abstractCysteine-rich 61 (Cyr61), from the CCN gene family, is a secreted and matrix-associated protein, which is involved in many cellular activities such as growth and differentiation. However, the effect of Cyr61 on migration activity in human chondrosarcoma cells is mostly unknown. Here, we found that Cyr61 increased the migration and expression of matrix metalloproteinase (MMP)-13 in human chondrosarcoma cells (JJ012 cells). RGD peptide, alpha v beta 3 monoclonal antibody and mitogen-activated protein kinase (MEK) inhibitors (PD98059 and U0126) but not RAD peptide inhibited the Cyr61-induced increase of the migration and MMP-13 upregulation of chondrosarcoma cells. Cyr61 stimulation increased the phosphorylation of focal adhesion kinase (FAK) and extracellular signal-regulated kinase (ERK). In addition, activator protein-1 (AP-1) decoy oligodeoxynucleotide also suppressed the MMP-13 messenger RNA and enzyme activity enhanced by Cyr61. Moreover, Cyr61 increased the binding of c-Fos and c-Jun to the AP-1 element on the MMP-13 promoter. Taken together, our results indicated that Cyr61 enhances the migration of chondrosarcoma cells by increasing MMP-13 expression through the alpha v beta 3 integrin receptor, FAK, ERK, c-Fos/c-Jun and AP-1 signal transduction pathway.en_US
dc.language.isoen_USzh_TW
dc.relationCarcinogenesisen_US
dc.relation.ispartofseriesCarcinogenesis, Volume 30, Issue 2, Page(s) 258-268.en_US
dc.relation.urihttp://dx.doi.org/10.1093/carcin/bgn284en_US
dc.subjectgrowth-factoren_US
dc.subjectsignaling pathwaysen_US
dc.subjectbreast-canceren_US
dc.subjectmatrixen_US
dc.subjectmetalloproteinasesen_US
dc.subjecttumor progressionen_US
dc.subjectup-regulationen_US
dc.subjectlung-canceren_US
dc.subjectccnen_US
dc.subjectfamilyen_US
dc.subjectinvasionen_US
dc.subjecttransductionen_US
dc.titleCyr61 increases migration and MMP-13 expression via alpha v beta 3 integrin, FAK, ERK and AP-1-dependent pathway in human chondrosarcoma cellsen_US
dc.typeJournal Articlezh_TW
dc.identifier.doi10.1093/carcin/bgn284zh_TW
item.grantfulltextnone-
item.fulltextno fulltext-
item.cerifentitytypePublications-
item.languageiso639-1en_US-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeJournal Article-
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