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標題: Brain-derived neurotrophic factor not associated with metabolic syndrome but inversely correlated with vascular cell adhesion molecule-1 in men without diabetes
作者: Lee, I.T.
Lee, W.J.
Tsai, I.C.
Liang, K.W.
Lin, S.Y.
Wan, C.J.
Fu, C.P.
Sheu, W.H.H.
關鍵字: Brain-derived neurotrophic factor;Metabolic syndrome;Vascular cell;adhesion molecule-1;Visceral adipose tissue;coronary-heart-disease;glucose-metabolism;alzheimers-disease;insulin-resistance;risk-factors;factor bdnf;obesity;serum;expression;atherosclerosis
Project: Clinica Chimica Acta
期刊/報告no:: Clinica Chimica Acta, Volume 413, Issue 9-10, Page(s) 944-948.
Background: Excessive visceral fat with unbalanced adipokines is a critical pathogenic factor of metabolic syndrome (MetS), which is associated with disorders of the central nervous system and cardiovascular disease. Because brain-derived neurotrophic factor (BDNF) plays an important role in neurons, we examined the relationship of BDNF to MetS, adipose tissue and biomarkers in men. Methods: Thirty-four non-diabetic men with MetS and another 24 age-matched men without MetS were enrolled. In addition to fasting blood samples, the area of adipose tissue at the waist was assessed by magnetic resonance imaging (MRI). Results: There was no significant difference in serum BDNF concentrations between men with or without MetS (40.9 +/- 8.0 vs. 432 +/- 6.1 ng/ml, P = 0235). However, the serum concentration of soluble vascular cell adhesion molecule-1 (VCAM-1) was higher in the subjects with a lower BDNF level (737 +/- 230 vs. 628 +/- 115 ng/ml, P=0.025). An inverse correlation between VCAM-1 and BDNF was observed (r = -0.391, P = 0.002). After adjusting for visceral adipose tissue, VCAM-1 was found to be independently associated with BDNF[95% confidence interval (-0.025, -0.005), P = 0.004]. Conclusion: These data show no difference in serum BDNF levels between the men with MetS and controls. However, serum BDNF was inversely correlated with serum VCAM-1 in men without diabetes. (C) 2012 Elsevier B.V. All rights reserved.
ISSN: 0009-8981
DOI: 10.1016/j.cca.2012.02.013
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