Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/68514
DC FieldValueLanguage
dc.contributor.authorLee, I.T.en_US
dc.contributor.authorLee, W.J.en_US
dc.contributor.authorTsai, I.C.en_US
dc.contributor.authorLiang, K.W.en_US
dc.contributor.authorLin, S.Y.en_US
dc.contributor.authorWan, C.J.en_US
dc.contributor.authorFu, C.P.en_US
dc.contributor.authorSheu, W.H.H.en_US
dc.date2012zh_TW
dc.date.accessioned2014-06-11T05:56:55Z-
dc.date.available2014-06-11T05:56:55Z-
dc.identifier.issn0009-8981zh_TW
dc.identifier.urihttp://hdl.handle.net/11455/68514-
dc.description.abstractBackground: Excessive visceral fat with unbalanced adipokines is a critical pathogenic factor of metabolic syndrome (MetS), which is associated with disorders of the central nervous system and cardiovascular disease. Because brain-derived neurotrophic factor (BDNF) plays an important role in neurons, we examined the relationship of BDNF to MetS, adipose tissue and biomarkers in men. Methods: Thirty-four non-diabetic men with MetS and another 24 age-matched men without MetS were enrolled. In addition to fasting blood samples, the area of adipose tissue at the waist was assessed by magnetic resonance imaging (MRI). Results: There was no significant difference in serum BDNF concentrations between men with or without MetS (40.9 +/- 8.0 vs. 432 +/- 6.1 ng/ml, P = 0235). However, the serum concentration of soluble vascular cell adhesion molecule-1 (VCAM-1) was higher in the subjects with a lower BDNF level (737 +/- 230 vs. 628 +/- 115 ng/ml, P=0.025). An inverse correlation between VCAM-1 and BDNF was observed (r = -0.391, P = 0.002). After adjusting for visceral adipose tissue, VCAM-1 was found to be independently associated with BDNF[95% confidence interval (-0.025, -0.005), P = 0.004]. Conclusion: These data show no difference in serum BDNF levels between the men with MetS and controls. However, serum BDNF was inversely correlated with serum VCAM-1 in men without diabetes. (C) 2012 Elsevier B.V. All rights reserved.en_US
dc.language.isoen_USzh_TW
dc.relationClinica Chimica Actaen_US
dc.relation.ispartofseriesClinica Chimica Acta, Volume 413, Issue 9-10, Page(s) 944-948.en_US
dc.relation.urihttp://dx.doi.org/10.1016/j.cca.2012.02.013en_US
dc.subjectBrain-derived neurotrophic factoren_US
dc.subjectMetabolic syndromeen_US
dc.subjectVascular cellen_US
dc.subjectadhesion molecule-1en_US
dc.subjectVisceral adipose tissueen_US
dc.subjectcoronary-heart-diseaseen_US
dc.subjectglucose-metabolismen_US
dc.subjectalzheimers-diseaseen_US
dc.subjectinsulin-resistanceen_US
dc.subjectrisk-factorsen_US
dc.subjectfactor bdnfen_US
dc.subjectobesityen_US
dc.subjectserumen_US
dc.subjectexpressionen_US
dc.subjectatherosclerosisen_US
dc.titleBrain-derived neurotrophic factor not associated with metabolic syndrome but inversely correlated with vascular cell adhesion molecule-1 in men without diabetesen_US
dc.typeJournal Articlezh_TW
dc.identifier.doi10.1016/j.cca.2012.02.013zh_TW
item.languageiso639-1en_US-
item.cerifentitytypePublications-
item.grantfulltextnone-
item.openairetypeJournal Article-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextno fulltext-
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