Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/68736
DC FieldValueLanguage
dc.contributor.authorLai, J.H.en_US
dc.contributor.authorShe, T.F.en_US
dc.contributor.authorJuang, Y.M.en_US
dc.contributor.authorTsay, Y.G.en_US
dc.contributor.authorHuang, A.H.en_US
dc.contributor.authorYu, S.L.en_US
dc.contributor.authorChen, J.J.W.en_US
dc.contributor.authorLai, C.C.en_US
dc.date2012zh_TW
dc.date.accessioned2014-06-11T05:57:14Z-
dc.date.available2014-06-11T05:57:14Z-
dc.identifier.issn0173-0835zh_TW
dc.identifier.urihttp://hdl.handle.net/11455/68736-
dc.description.abstractLung cancer is a common malignancy and has a poor overall prognosis. Widespread metastasis is a common phenomenon in non-small cell lung cancer (NSCLC). It has been demonstrated that cancer relapse and survival can be predicted by the presence of a five-microRNA (miRNA) signature independent of stage or histologic type in NSCLC patients. Among the five miRNAs in the signature, miR-372 has been shown to play a significant role in metastasis and in the development of human testicular germ cell tumors. In addition, there is evidence that miR-372 posttranscriptionally downregulates large tumor suppressor, homolog 2 (Lats2), resulting in tumorigenesis and proliferation. To further investigate the cellular mechanisms involved in miR-372-induced silencing, we conducted a comparative proteomic analysis of NSCLC CL 10 cells expressing miRNA-372 and/or vector only by using two-dimensional gel electrophoresis (2DE), two-dimensional difference gel electrophoresis (2D-DIGE), and LC/MS/MS. Proteins identified as being up- or downregulated were further classified according to their biological functions. Many of the proteins identified in our study may be potential diagnostic biomarkers of NSCLC, particularly phosphorylated eIF4A-I.en_US
dc.language.isoen_USzh_TW
dc.relationElectrophoresisen_US
dc.relation.ispartofseriesElectrophoresis, Volume 33, Issue 4, Page(s) 675-688.en_US
dc.relation.urihttp://dx.doi.org/10.1002/elps.201100329en_US
dc.subjectCL 1u0en_US
dc.subjectComparative proteomicsen_US
dc.subjectMiR-372en_US
dc.subjectNon-small cell lung canceren_US
dc.subject(NSCLC)en_US
dc.subjectEukaryotic initiation factor 4A-Ien_US
dc.subjecthepatocellular-carcinomaen_US
dc.subjectcanceren_US
dc.subjectmicrornasen_US
dc.subjectsurvivalen_US
dc.subjectproteinen_US
dc.subjectoverexpressionen_US
dc.subjecttransformationen_US
dc.subjectassociationen_US
dc.subjecttechnologyen_US
dc.subjectactivationen_US
dc.titleComparative proteomic profiling of human lung adenocarcinoma cells (CL 1-0) expressing miR-372en_US
dc.typeJournal Articlezh_TW
dc.identifier.doi10.1002/elps.201100329zh_TW
item.languageiso639-1en_US-
item.grantfulltextnone-
item.cerifentitytypePublications-
item.fulltextno fulltext-
item.openairetypeJournal Article-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
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