Please use this identifier to cite or link to this item:
|標題:||Luteolin Suppresses Inflammatory Mediator Expression by Blocking the Akt/NF kappa B Pathway in Acute Lung Injury Induced by Lipopolysaccharide in Mice||作者:||Li, Y.C.
|關鍵字:||respiratory-distress-syndrome;neutrophils;cells;activation;macrophage;molecules;toxicity;fibrosis;therapy||Project:||Evidence-Based Complementary and Alternative Medicine||期刊/報告no：:||Evidence-Based Complementary and Alternative Medicine.||摘要:||
Acute lung injury (ALI), instilled by lipopolysaccharide (LPS), is a severe illness with excessive mortality and has no specific treatment strategy. Luteolin is an anti-inflammatory flavonoid and widely distributed in the plants. Pretreatment with luteolin inhibited LPS-induced histological changes of ALI and lung tissue edema. In addition, LPS-induced inflammatory responses, including increased vascular permeability, tumor necrosis factor (TNF)-alpha and interleukin (IL)-6 production, and expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), were also reduced by luteolin in a concentration-dependent manner. Furthermore, luteolin suppressed activation of NF kappa B and its upstream molecular factor, Akt. These results suggest that the protection mechanism of luteolin is by inhibition of NF kappa B activation possibly via Akt.
|Appears in Collections:||期刊論文|
Show full item record
TAIR Related Article
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.