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標題: Luteolin Suppresses Inflammatory Mediator Expression by Blocking the Akt/NF kappa B Pathway in Acute Lung Injury Induced by Lipopolysaccharide in Mice
作者: Li, Y.C.
Yeh, C.H.
Yang, M.L.
Kuan, Y.H.
關鍵字: respiratory-distress-syndrome;neutrophils;cells;activation;macrophage;molecules;toxicity;fibrosis;therapy
Project: Evidence-Based Complementary and Alternative Medicine
期刊/報告no:: Evidence-Based Complementary and Alternative Medicine.
Acute lung injury (ALI), instilled by lipopolysaccharide (LPS), is a severe illness with excessive mortality and has no specific treatment strategy. Luteolin is an anti-inflammatory flavonoid and widely distributed in the plants. Pretreatment with luteolin inhibited LPS-induced histological changes of ALI and lung tissue edema. In addition, LPS-induced inflammatory responses, including increased vascular permeability, tumor necrosis factor (TNF)-alpha and interleukin (IL)-6 production, and expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), were also reduced by luteolin in a concentration-dependent manner. Furthermore, luteolin suppressed activation of NF kappa B and its upstream molecular factor, Akt. These results suggest that the protection mechanism of luteolin is by inhibition of NF kappa B activation possibly via Akt.
ISSN: 1741-427X
DOI: 10.1155/2012/383608
Appears in Collections:期刊論文

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