Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/68940
DC FieldValueLanguage
dc.contributor.authorChen, Y.T.en_US
dc.contributor.authorHsu, C.I.en_US
dc.contributor.authorHung, D.Z.en_US
dc.contributor.authorMatsuura, I.en_US
dc.contributor.authorLiao, J.W.en_US
dc.date2011zh_TW
dc.date.accessioned2014-06-11T05:57:33Z-
dc.date.available2014-06-11T05:57:33Z-
dc.identifier.issn0278-6915zh_TW
dc.identifier.urihttp://hdl.handle.net/11455/68940-
dc.description.abstractCardiovascular effects have often been found in 2-chloroethanol (2-CE) intoxicated patients, but the 2-CE elicits cardiovascular toxicity mechanism is not clear. Recently, we have found that chloroacetaldehyde (CAA) accumulation in 2-CE-intoxicated rat's blood and play an important role in 2-CE intoxication. In this study, we used an isolated rat atrium model to examine the cardiotoxicity of 2-CE and CAA. Results indicated that 2-CE did not cause tension arrest in isolated rat right atria, but CAA did. 2-CE caused tension inhibition in the isolated rat left atria. In addition, CAA caused significant tension inhibition and contracture in the isolated rat left atria. Nifedipine, an L-type calcium channel blocker, decreased CAA-induced tension inhibition and contracture. Meanwhile, atrial nNOS and calmodulin (CaM) had significantly greater expression in the 2-CE group and the CM group than control group. Nifedipine could decrease CAA-induced nNOS and CaM expression. 2-CE-induced cardiovascular toxicity might be due to its metabolite CM. CAA-induced cardiovascular toxicity might be mediated by calcium channel and nifedipine protected against nNOS-triggered cardiovascular effects. (C) 2011 Elsevier Ltd. All rights reserved.en_US
dc.language.isoen_USzh_TW
dc.relationFood and Chemical Toxicologyen_US
dc.relation.ispartofseriesFood and Chemical Toxicology, Volume 49, Issue 5, Page(s) 1063-1067.en_US
dc.relation.urihttp://dx.doi.org/10.1016/j.fct.2011.01.013en_US
dc.titleEffects of chloroacetaldehyde in 2-chloroethanol-induced cardiotoxicityen_US
dc.typeJournal Articlezh_TW
dc.identifier.doi10.1016/j.fct.2011.01.013zh_TW
item.openairetypeJournal Article-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.languageiso639-1en_US-
item.grantfulltextnone-
item.fulltextno fulltext-
item.cerifentitytypePublications-
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