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標題: Multi-Channel SQUID-Based Ultra-High-Sensitivity In-Vitro Detections for Bio-Markers of Alzheimer's Disease Via Immunomagnetic Reduction
作者: Chiu, M.J.
Horng, H.E.
Chieh, J.J.
Liao, S.H.
Chen, C.H.
Shih, B.Y.
Yang, C.C.
Lee, C.L.
Chen, T.F.
Yang, S.Y.
Hong, C.Y.
Yang, H.C.
Project: Ieee Transactions on Applied Superconductivity
期刊/報告no:: Ieee Transactions on Applied Superconductivity, Volume 21, Issue 3, Page(s) 477-480.
Via immunomagnetic reduction assay, bio-molecules can be quantitatively detected with the aid of bio-functionalized magnetic nanoparticles, which are used as labeling markers for specific bio-molecules. To achieve an ultra-high sensitivity in the detection of bio-molecules, the superconducting quantum interference device (SQUID) looks very promising as a sensor for the magnetic signal that are related to the concentration of the detected bio-molecules. We had developed a single channel SQUID-based magnetosusceptometer, but for increasing the detection through-put, we have developed a multi-channel SQUID-based magnetosusceptometer. In this work, the design and the working principle of a 4-channel SQUID-based magnetosusceptometer are introduced. By utilizing scanning technology, 4 samples can be logged into a SQUID-based magnetosusceptometer simultaneously. Be noted that only one single SQUID magnetometer has been used in the magnetosusceptometer. The precision and the sensitivity of detecting bio-molecules by using a 4-channel SQUID-based magnetosusceptometer have been investigated. The detected bio-molecules are biomarkers for Alzheimer's disease.
ISSN: 1051-8223
DOI: 10.1109/tasc.2010.2087304
Appears in Collections:期刊論文

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