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|標題:||d-pinitol inhibits RANKL-induced osteoclastogenesis||作者:||Liu, S.C.
|關鍵字:||D-pinitol;Osteoclasts;Chinese herb;NF-kappa B;nf-kappa-b;colony-stimulating factor;differentiation factor;cells;macrophages;activation;receptor;pathway;domain;gene||Project:||International Immunopharmacology||期刊/報告no：:||International Immunopharmacology, Volume 12, Issue 3, Page(s) 494-500.||摘要:||
Numerous studies have indicated that inflammatory cytokines play a major role in osteoclastogenesis, leading to the bone resorption that is frequently associated with osteoporosis. D-pinitol, a 3-methoxy analogue of D-chiroinositol, was identified as an active principle in soy foods and legumes. Here we found that D-pinitol markedly inhibited the receptor activator of nuclear factor kappa B ligand (RANKL)-induced osteoclastic differentiation from bone marrow stromal cells and RAW264.7 macrophage cells. In addition, D-pinitol also reduced RANKL-induced p38 and JNK phosphorylation. Furthermore, RANKL-mediated increase of IKK, I kappa B alpha, and p65 phosphorylation and NF-kappa B-luciferase activity was inhibited by D-pinitol. However, D-pinitol did not affect the proliferation and differentiation of osteoblasts. In addition, D-pinitol also prevented the bone loss induced by ovariectomy in vivo. Our data suggest that D-pinitol inhibits osteoclastogenesis from bone marrow stromal cells and macrophage cells via attenuated RANKL-induced p38, JNK, and NF-kappa B activation, which in turn protect bone loss from ovariectomy. (C) 2012 Elsevier B.V. All rights reserved.
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