Please use this identifier to cite or link to this item:
標題: Collagen type 3 alpha 1 polymorphism and risk of pelvic organ prolapse
作者: Chen, H.Y.
Chung, Y.W.
Lin, W.Y.
Wang, J.C.
Tsai, F.J.
Tsai, C.H.
關鍵字: Genotype;Collagen type 3 alpha 1 polymorphism;Pelvic organ prolapses;urinary-incontinence;cesarean-section;floor disorders;ligaments;receptors;women
Project: International Journal of Gynecology & Obstetrics
期刊/報告no:: International Journal of Gynecology & Obstetrics, Volume 103, Issue 1, Page(s) 55-58.
Objective: To investigate whether pelvic organ prolapse (POP) is associated with collogen 3 alpha 1 (COL3A1) polymorphisms and other factors. Methods: A case-control association study was conducted with 84 women affected with POP and 147 controls. The genotypes of nucleotides COL3A1 rs1800255 and COL3A1 rs1801184 polymorphisms were ascertained by polymerase chain reaction and restriction fragment length polymorphism analysis. Results: The distribution of the COL3A1 rs1800255 genotypes was significantly different among affected women and controls. Older age and incidence of COL3A1 rs1800255 genotype AA were significantly associated with risk of POP. Conclusion: There may be an association between COL3A1 genotype and risk of POP. (c) 2008 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.
ISSN: 0020-7292
DOI: 10.1016/j.ijgo.2008.05.031
Appears in Collections:期刊論文

Show full item record

Google ScholarTM




Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.