Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/69401
DC FieldValueLanguage
dc.contributor.authorChen, T.C.en_US
dc.contributor.authorHung, Y.C.en_US
dc.contributor.authorLin, T.Y.en_US
dc.contributor.authorChang, H.W.en_US
dc.contributor.authorChiang, I.P.en_US
dc.contributor.authorChen, Y.Y.en_US
dc.contributor.authorChow, K.C.en_US
dc.date2011zh_TW
dc.date.accessioned2014-06-11T05:58:16Z-
dc.date.available2014-06-11T05:58:16Z-
dc.identifier.issn1107-3756zh_TW
dc.identifier.urihttp://hdl.handle.net/11455/69401-
dc.description.abstractOur aim was to determine the association of human papillomavirus (HPV) infection with the expression of ATPase family AAA domain containing 3A (ATAD3A), an anti-autophagy factor, in uterine cervical cancer (UCC). The HPV genotype was determined by an Easychip HPV blot assay. ATAD3A expression was determined by immunohistochemical staining. High-risk HPV (hrHPV) was detected in 184 (88.9%) of 207 UCC cases. ATAD3A expression was detected in 164 (79.2%) UCC cases. A significant correlation was found between ATAD3A expression and the presence of hrHPV (p<0.001),FIGO stage (p=0.014), lymph node involvement (p=0.001), c-MET expression (p<0.001), interleukin-8 (p=0.03) and patient survival (p=0.0016). Interestingly, silencing of E6/E7 expression decreased ATAD3A expression and cell survival. Moreover, knockdown of ATAD3A (ATAD3A(kd)) expression or addition of resveratrol, increased cellular autophagy and apoptosis and reduced drug resistance. Resveratrol reduced ATAD3A expression, and increased abrasion of the mitochondrial outer membrane as well as numbers of autophagosomes, the phenomena that were frequently found in ATAD3A(kd) cells. In conclusion, our results show that HPV infection correlates with increased ATAD3A expression and drug resistance in UCC. Persistent HPV infection may stabilize ATAD3A expression to inhibit cell autophagy and apoptosis as well as to increase drug resistance.en_US
dc.language.isoen_USzh_TW
dc.relationInternational Journal of Molecular Medicineen_US
dc.relation.ispartofseriesInternational Journal of Molecular Medicine, Volume 28, Issue 5, Page(s) 689-696.en_US
dc.relation.urihttp://dx.doi.org/10.3892/ijmm.2011.743en_US
dc.subjecthigh risk HPVen_US
dc.subjectATAD3Aen_US
dc.subjectdrug resistanceen_US
dc.subjectautophagyen_US
dc.subjectprognosisen_US
dc.subjectlung adenocarcinoma cellsen_US
dc.subjectdihydrodiol dehydrogenaseen_US
dc.subjectapoptotic factoren_US
dc.subjectup-regulationen_US
dc.subjectcisplatinen_US
dc.subjectoverexpressionen_US
dc.subjectresistanceen_US
dc.subjectcarcinomaen_US
dc.subjectcarcinogenesisen_US
dc.subjectmitochondriaen_US
dc.titleHuman papillomavirus infection and expression of ATPase family AAA domain containing 3A, a novel anti-autophagy factor, in uterine cervical canceren_US
dc.typeJournal Articlezh_TW
dc.identifier.doi10.3892/ijmm.2011.743zh_TW
item.languageiso639-1en_US-
item.cerifentitytypePublications-
item.grantfulltextnone-
item.openairetypeJournal Article-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextno fulltext-
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