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|標題:||Safrole Induces Apoptosis in Human Oral Cancer HSC-3 Cells||作者:||Yu, F.S.
|關鍵字:||safrole;oral cancer HSC-3 cells;apoptosis;caspase cascades;xenograft;model;upper aerodigestive tract;mitochondria-dependent pathways;endoplasmic-reticulum stress;dna-adducts;alcohol-consumption;activation pathway;tongue cancer;scc-4 cells;in-vitro;risk||Project:||Journal of Dental Research||期刊/報告no：:||Journal of Dental Research, Volume 90, Issue 2, Page(s) 168-174.||摘要:||
Phytochemicals have been used as potential chemopreventive or chemotherapeutic agents. However, there are data suggesting a mutagenic effect of some phytochemicals. We hypothesized that safrole would have anticancer effects on human oral squamous cell carcinoma HSC-3 cells. Safrole decreased the percentage of viable HSC-3 cells via induction of apoptosis by an increased level of cytosolic Ca(2+) and a reduction in the mitochondrial membrane potential (Delta Psi(m)). Changes in the membrane potential were associated with changes in the Bax, release of cytochrome c from mitochondria, and activation of downstream caspases-9 and -3, resulting in apoptotic cell death. In vivo studies also showed that safrole reduced the size and volume of an HSC-3 solid tumor on a xenograft athymic nu/nu mouse model. Western blotting and flow cytometric analysis studies confirmed that safrole-mediated apoptotic cell death of HSC-3 cells is regulated by cytosolic Ca(2+) and by mitochondria-and Fas-dependent pathways.
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