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標題: Efficacy and safety of nanohybrids comprising silver nanoparticles and silicate clay for controlling Salmonella infection
作者: Chiao, S.H.
Lin, S.H.
Shen, C.I.
Liao, J.W.
Bau, I.J.
Wei, J.C.
Tseng, L.P.
Hsu, S.H.
Lai, P.S.
Lin, S.Z.
Lin, J.J.
Su, H.L.
關鍵字: silver;nanoparticle;biocompatibility;infection;cytotoxicity;escherichia-coli;poly(styrene-co-maleic acid);antibacterial activity;staphylococcus-aureus;ingested silver;oral toxicity;in-vitro;genotoxicity;kidney;tissue
Project: International Journal of Nanomedicine
期刊/報告no:: International Journal of Nanomedicine, Volume 7, Page(s) 2421-2432.
Developing effective and safe drugs is imperative for replacing antibiotics and controlling multidrug-resistant microbes. Nanoscale silicate platelet (NSP) and its nanohybrid, silver nanoparticle/NSP (AgNP/NSP), have been developed, and the nanohybrids show a strong and general antibacterial activity in vitro. Here, their efficacy for protecting Salmonella-infected chicks from fatality and septicemia was evaluated. Both orally administrated NSP and AgNP/NSP, but not AgNPs alone, effectively reduced the systemic Salmonella infection and mortality. In addition, quantitative Ag analyses demonstrated that Ag deposition from AgNP/NSP in the intestines was less than that from conventional AgNPs, indicating that the presence of NSP for immobilizing AgNPs reduced Ag accumulation in tissue and improved the safety of AgNPs. These in vivo results illustrated that both NSP and AgNP/NSP nanohybrid represent potential agents for controlling enteric bacterial infections.
ISSN: 1178-2013
DOI: 10.2147/ijn.s31594
Appears in Collections:期刊論文

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