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標題: Fabrication of pillared PLGA microvessel scaffold using femtosecond laser ablation
作者: Wang, H.W.
Cheng, C.W.
Li, C.W.
Chang, H.W.
Wu, P.H.
Wang, G.J.
關鍵字: femtosecond laser ablation;pillared microvessel scaffold;polylactic-co-glycolic acid;bovine endothelial cells;circular microchannels;substrate;networks;pulses;glass
Project: International Journal of Nanomedicine
期刊/報告no:: International Journal of Nanomedicine, Volume 7, Page(s) 1865-1873.
One of the persistent challenges confronting tissue engineering is the lack of intrinsic microvessels for the transportation of nutrients and metabolites. An artificial microvascular system could be a feasible solution to this problem. In this study, the femtosecond laser ablation technique was implemented for the fabrication of pillared microvessel scaffolds of polylactic-co-glycolic acid (PLGA). This novel scaffold facilitates implementation of the conventional cell seeding process. The progress of cell growth can be observed in vitro by optical microscopy. The problems of becoming milky or completely opaque with the conventional PLGA scaffold after cell seeding can be resolved. In this study, PLGA microvessel scaffolds consisting of 47 mu m x 80 mu m pillared branches were produced. Results of cell culturing of bovine endothelial cells demonstrate that the cells adhere well and grow to surround each branch of the proposed pillared microvessel networks.
ISSN: 1178-2013
DOI: 10.2147/ijn.s29969
Appears in Collections:期刊論文

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