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|標題:||Melamine-Induced Urolithiasis in a Drosophila Model||作者:||Chen, W.C.
|關鍵字:||Drosophila melanogaster;melamine;urolithiasis;potassium citrate;urinary-bladder;calculi;stones;kidney;rats;carcinogenicity;nephrolithiasis;toxicity;crystals;children||Project:||Journal of Agricultural and Food Chemistry||期刊/報告no：:||Journal of Agricultural and Food Chemistry, Volume 60, Issue 10, Page(s) 2753-2757.||摘要:||
Melamine-tainted food can induce renal stones in both humans and animals. We have previously reported a novel Drosophila model for the study of renal stone disease. In addition to hyperoxaluria-causing agents, we also tested herein the effect of melamine on crystal formation in Drosophila. The results indicate that administration of melamine alone caused crystal formation in a dose-dependent manner. The crystals also appeared after ingestion of melamine for 3 weeks in the Malpighian tubules of Drosophila when viewed with polarized light. Administration of potassium citrate (K citrate) was found to significantly ameliorate the melamine-induced reduction of lifespan. However, administration of K citrate failed to reduce the quantity of crystals. Because calcium oxalate is not the major crystal induced by melamine, the predominant components of melamine-induced crystals and the potential crystal inhibitors warrant further investigation.
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