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標題: Melamine-Induced Urolithiasis in a Drosophila Model
作者: Chen, W.C.
Lin, W.Y.
Chen, H.Y.
Chang, C.H.
Tsai, F.J.
Man, K.M.
Shen, J.L.
Chen, Y.H.
關鍵字: Drosophila melanogaster;melamine;urolithiasis;potassium citrate;urinary-bladder;calculi;stones;kidney;rats;carcinogenicity;nephrolithiasis;toxicity;crystals;children
Project: Journal of Agricultural and Food Chemistry
期刊/報告no:: Journal of Agricultural and Food Chemistry, Volume 60, Issue 10, Page(s) 2753-2757.
Melamine-tainted food can induce renal stones in both humans and animals. We have previously reported a novel Drosophila model for the study of renal stone disease. In addition to hyperoxaluria-causing agents, we also tested herein the effect of melamine on crystal formation in Drosophila. The results indicate that administration of melamine alone caused crystal formation in a dose-dependent manner. The crystals also appeared after ingestion of melamine for 3 weeks in the Malpighian tubules of Drosophila when viewed with polarized light. Administration of potassium citrate (K citrate) was found to significantly ameliorate the melamine-induced reduction of lifespan. However, administration of K citrate failed to reduce the quantity of crystals. Because calcium oxalate is not the major crystal induced by melamine, the predominant components of melamine-induced crystals and the potential crystal inhibitors warrant further investigation.
ISSN: 0021-8561
DOI: 10.1021/jf204647p
Appears in Collections:期刊論文

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