Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/69632
DC FieldValueLanguage
dc.contributor.authorChen, W.C.en_US
dc.contributor.authorLin, W.Y.en_US
dc.contributor.authorChen, H.Y.en_US
dc.contributor.authorChang, C.H.en_US
dc.contributor.authorTsai, F.J.en_US
dc.contributor.authorMan, K.M.en_US
dc.contributor.authorShen, J.L.en_US
dc.contributor.authorChen, Y.H.en_US
dc.date2012zh_TW
dc.date.accessioned2014-06-11T05:58:36Z-
dc.date.available2014-06-11T05:58:36Z-
dc.identifier.issn0021-8561zh_TW
dc.identifier.urihttp://hdl.handle.net/11455/69632-
dc.description.abstractMelamine-tainted food can induce renal stones in both humans and animals. We have previously reported a novel Drosophila model for the study of renal stone disease. In addition to hyperoxaluria-causing agents, we also tested herein the effect of melamine on crystal formation in Drosophila. The results indicate that administration of melamine alone caused crystal formation in a dose-dependent manner. The crystals also appeared after ingestion of melamine for 3 weeks in the Malpighian tubules of Drosophila when viewed with polarized light. Administration of potassium citrate (K citrate) was found to significantly ameliorate the melamine-induced reduction of lifespan. However, administration of K citrate failed to reduce the quantity of crystals. Because calcium oxalate is not the major crystal induced by melamine, the predominant components of melamine-induced crystals and the potential crystal inhibitors warrant further investigation.en_US
dc.language.isoen_USzh_TW
dc.relationJournal of Agricultural and Food Chemistryen_US
dc.relation.ispartofseriesJournal of Agricultural and Food Chemistry, Volume 60, Issue 10, Page(s) 2753-2757.en_US
dc.relation.urihttp://dx.doi.org/10.1021/jf204647pen_US
dc.subjectDrosophila melanogasteren_US
dc.subjectmelamineen_US
dc.subjecturolithiasisen_US
dc.subjectpotassium citrateen_US
dc.subjecturinary-bladderen_US
dc.subjectcalculien_US
dc.subjectstonesen_US
dc.subjectkidneyen_US
dc.subjectratsen_US
dc.subjectcarcinogenicityen_US
dc.subjectnephrolithiasisen_US
dc.subjecttoxicityen_US
dc.subjectcrystalsen_US
dc.subjectchildrenen_US
dc.titleMelamine-Induced Urolithiasis in a Drosophila Modelen_US
dc.typeJournal Articlezh_TW
dc.identifier.doi10.1021/jf204647pzh_TW
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeJournal Article-
item.cerifentitytypePublications-
item.fulltextno fulltext-
item.languageiso639-1en_US-
item.grantfulltextnone-
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